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MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [ Homo sapiens (human) ]

Gene ID: 4245, updated on 9-Dec-2018

Summary

Official Symbol
MGAT1provided by HGNC
Official Full Name
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:7044
See related
Ensembl:ENSG00000131446 MIM:160995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GnTI; MGAT; GLCT1; GLYT1; GNT-1; GNT-I; GLCNAC-TI
Summary
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 30.2), spleen (RPKM 29.9) and 25 other tissues See more
Orthologs

Genomic context

See MGAT1 in Genome Data Viewer
Location:
5q35.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (180790541..180815635, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180217541..180237939, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 17, pseudogene Neighboring gene olfactory receptor family 2 subfamily Y member 1 Neighboring gene uncharacterized LOC105377766 Neighboring gene long intergenic non-protein coding RNA 847 Neighboring gene hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
NHGRI GWA Catalog
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (MGAT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env trimers expressing in the absence of GNTI have a mass of 394-390 kDa compared to the parent trimers of about 420 kDa. HIV-1 produced in the absence of GNTI is infectious PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
UDP-N-acetylglucosamine catabolic process IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular vesicle HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Names
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
glcNAc-T I
NP_001108089.1
NP_001108090.1
NP_001108091.1
NP_001108092.1
NP_002397.2
XP_005265972.1
XP_011532861.1
XP_011532863.1
XP_011532864.1
XP_011532865.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032928.2 RefSeqGene

    Range
    10836..30112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001114617.1NP_001108089.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_001108089.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AK094130, CA426780, DB270226, M55621
    Consensus CDS
    CCDS4458.1
    UniProtKB/Swiss-Prot
    P26572
    Related
    ENSP00000377010.3, ENST00000393340.7
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  2. NM_001114618.1NP_001108090.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_001108090.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AK094130, BG337235, CA426780, M55621
    Consensus CDS
    CCDS4458.1
    UniProtKB/Swiss-Prot
    P26572
    Related
    ENSP00000404718.2, ENST00000446023.6
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  3. NM_001114619.1NP_001108091.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_001108091.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    CA426780, DC383950, M55621
    Consensus CDS
    CCDS4458.1
    UniProtKB/Swiss-Prot
    P26572
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  4. NM_001114620.1NP_001108092.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_001108092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    CA426780, DC383950, M55621
    Consensus CDS
    CCDS4458.1
    UniProtKB/Swiss-Prot
    P26572
    Related
    ENSP00000402838.2, ENST00000427865.2
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  5. NM_001364377.1NP_001351306.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  6. NM_001364379.1NP_001351308.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  7. NM_001364380.1NP_001351309.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  8. NM_001364381.1NP_001351310.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, AK057194
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  9. NM_001364382.1NP_001351311.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, DA471492
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  10. NM_001364383.1NP_001351312.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, BP300306
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  11. NM_001364384.1NP_001351313.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  12. NM_001364385.1NP_001351314.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, DA273577
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  13. NM_001364386.1NP_001351315.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  14. NM_001364387.1NP_001351316.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  15. NM_001364388.1NP_001351317.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, DA292271
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  16. NM_001364389.1NP_001351318.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, DA440728
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  17. NM_001364390.1NP_001351319.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, DA467596
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  18. NM_001364391.1NP_001351320.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, DA997500
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  19. NM_001364392.1NP_001351321.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, DB050338
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  20. NM_001364393.1NP_001351322.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, DA030335
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  21. NM_001364394.1NP_001351323.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, DA028514
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  22. NM_001364395.1NP_001351324.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  23. NM_002406.3NP_002397.2  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_002397.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. Variants 1-23 all encode the same protein.
    Source sequence(s)
    AC022413, CA426780, CN409895, M55621
    Consensus CDS
    CCDS4458.1
    UniProtKB/Swiss-Prot
    P26572
    Related
    ENSP00000311888.4, ENST00000307826.4
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family

RNA

  1. NR_157150.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) uses an alternate 5' and 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
    Source sequence(s)
    AC022413, AV717693
  2. NR_157151.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) uses an alternate 5' and 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
    Source sequence(s)
    AC022413
  3. NR_157152.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) uses an alternate 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
    Source sequence(s)
    AC022413
  4. NR_157153.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) uses an alternate 5' and 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
    Source sequence(s)
    AC022413
  5. NR_157154.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28) uses an alternate 5' and 3' exon structure compared to variant 6. This variant is represented as non-coding because it lacks the entire coding region found in variant 6.
    Source sequence(s)
    AC022413, AI188463

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    180790541..180815635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534563.2XP_011532865.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P26572
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  2. XM_011534562.1XP_011532864.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P26572
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  3. XM_011534559.2XP_011532861.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P26572
    Related
    ENSP00000332073.3, ENST00000333055.8
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  4. XM_011534561.2XP_011532863.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P26572
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
  5. XM_005265915.2XP_005265972.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P26572
    Conserved Domains (1) summary
    pfam03071
    Location:12444
    GNT-I; GNT-I family
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