U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRXL2A peroxiredoxin like 2A [ Gallus gallus (chicken) ]

Gene ID: 423625, updated on 13-Apr-2026
Official Symbol
PRXL2Aprovided by CGNC
Official Full Name
peroxiredoxin like 2Aprovided by CGNC
Primary source
CGNC:1725
See related
Ensembl:ENSGALG00010010967
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PAMM; FAM213A; SELENOU; C10ORF58; C6H10orf58
Summary
The protein encoded by this gene belongs to a subfamily of FAM213A/selenoprotein U (SelU), within a peroxiredoxin-like FAM213 superfamily. SelU is unusual in that it has restricted phylogenetic distribution in vertebrates, such as in chicken and fish. Other vertebrate members of this family, including mammals, contain cysteine-containing homologues. SelU proteins contain UxxC (U for selenocysteine and C for cysteine) motif in place of the catalytic CxxC motif found in cysteine-containing homologues. The latter function as redox regulatory proteins, suggesting a similar role for SelU proteins. Like majority of selenoproteins, SelU contains a single selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PRXL2A in Genome Data Viewer
Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (5066999..5078169, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (4951690..4962890, complement)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 4B Neighboring gene Rap1 GTPase-GDP dissociation stimulator 1 Neighboring gene tetraspanin 14 Neighboring gene exosome component 3 Neighboring gene DPY30 domain containing 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. Castellano S, et al. EMBO Rep, 2004 Jan. PMID 14710190, Free PMC Article
  2. Selenoprotein Gene Nomenclature. Gladyshev VN, et al. J Biol Chem, 2016 Nov 11. PMID 27645994, Free PMC Article
  3. Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index. Carre W, et al. Physiol Genomics, 2006 May 16. PMID 16554550
  4. Composition and evolution of the vertebrate and mammalian selenoproteomes. Mariotti M, et al. PLoS One, 2012. PMID 22479358, Free PMC Article
  5. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Preferred Names
selenoprotein U
Names
Protein PAMM
UPF0765 protein C10orf58 homolog
family with sequence similarity 213 member A
peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytes
peroxiredoxin-like 2 activated in M-CSF stimulated monocytes
redox-regulatory protein FAM213A
redox-regulatory protein PAMM

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193518.2 → NP_001180447.1  selenoprotein U

    See identical proteins and their annotated locations for NP_001180447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript derived from an upstream promoter. Variants 1 and 2 encode the same selenoprotein.
    Source sequence(s)
    JAENSK010000227
    UniProtKB/Swiss-Prot
    Q5ZI34
    UniProtKB/TrEMBL
    A0A0F6YFH3, A0A1D5PW05, A0ACD6B774
    Related
    ENSGALP00010014887.1, ENSGALT00010026263.1
    Conserved Domains (1) summary
    cd02970
    Location:49 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  2. NM_001193519.3 → NP_001180448.1  selenoprotein U

    See identical proteins and their annotated locations for NP_001180448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' non-coding exon derived from a downstream promoter, compared to variant 1. Variants 1 and 2 encode the same selenoprotein.
    Source sequence(s)
    JAENSK010000227
    UniProtKB/Swiss-Prot
    Q5ZI34
    UniProtKB/TrEMBL
    A0A0F6YFH3, A0A1D5PW05, A0ACD6B774
    Conserved Domains (1) summary
    cd02970
    Location:49 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5066999..5078169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4951690..4962890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_027494.1: Suppressed sequence

    Description
    NR_027494.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.

  2. NR_027495.1: Suppressed sequence

    Description
    NR_027495.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZI34.2 GenPept UniProtKB/Swiss-Prot:Q5ZI34

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials