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Ire1 Inositol-requiring enzyme-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42358, updated on 28-Aug-2019

Summary

Official Symbol
Ire1provided by FlyBase
Official Full Name
Inositol-requiring enzyme-1provided by FlyBase
Primary source
FLYBASE:FBgn0261984
Locus tag
Dmel_CG4583
Gene type
protein coding
RNA name
Inositol-requiring enzyme-1
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4583; dire-1; dIRE1; Dmel\CG4583; ERN1; Ire; ire-1; Ire-1; IRE-like; ire1; IRE1

Genomic context

See Ire1 in Genome Data Viewer
Location:
92B1-92B7; 3-67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19853908..19861291, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15679630..15687013, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Threonine-AGT 1-7 Neighboring gene branchless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
endoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
IRE1-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IRE1-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
compound eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT compound eye photoreceptor fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
rhabdomere morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
IRE1-TRAF2-ASK1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Inositol-requiring enzyme-1
Names
CG4583-PB
Ire
Ire1-PB
inositol required 1
ire-1
NP_001097839.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19853908..19861291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104369.2NP_001097839.1  Inositol-requiring enzyme-1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097839.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JR46
    Related
    FBpp0112160, FBtr0113248
    Conserved Domains (4) summary
    cd09769
    Location:53321
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:817941
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:552812
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13982
    Location:545813
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
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