HSPA2 heat shock protein family A (Hsp70) member 2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: HSPA2provided by CGNC
Official Full Name: heat shock protein family A (Hsp70) member 2provided by CGNC
Primary source: CGNC:51984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: HSP70; Hsc80; cHsp70a
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (52384623..52386942, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (52363374..52365693, complement)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-enzyme Q10 can protect chicken hearts from in vivo heat stress by inducing HSF1 binding activity and Hsp70 expression.
Title: Co-enzyme Q10 protects chicken hearts from in vivo heat stress via inducing HSF1 binding activity and Hsp70 expression.
data indicate that HSP70 is part of the receptor complex of Avian infectious bronchitis virus (IBV) and might help to understand the mechanism of S-mediated cell entry of IBV
Title: Heat shock protein 70 in lung and kidney of specific-pathogen-free chickens is a receptor-associated protein that interacts with the binding domain of the spike protein of infectious bronchitis virus.
Data suggest that exposure to high environmental temperature up-regulates expression of heat shock factor 1 (HSF1) mRNA, HSF3 mRNA, and heat shock protein 70 (HSP70) mRNA/protein in liver, heart, and breast muscle; dietary supplementation with manganese down-regulates expression of HSP70 in breast muscle.
Title: Effect of dietary manganese on antioxidant status and expressions of heat shock proteins and factors in tissues of laying broiler breeders under normal and high environmental temperatures.
High incubation temperature and threonine dietary level improve ileum response against post-hatch Salmonella enteritidis inoculation in broiler chicks by up-regulating the expression of HSP70 and MUC2.
Title: High Incubation Temperature and Threonine Dietary Level Improve Ileum Response Against Post-Hatch Salmonella Enteritidis Inoculation in Broiler Chicks.
variation in chicken HSP70 was abundant between and within species
Title: Analysis of genetic diversity of the heat shock protein 70 gene on the basis of abundant sequence polymorphisms in chicken breeds.
The effects of transport time on HSP70 expression, stress, and meat quality are reported.
Title: The effect of transportation of broilers during summer on the expression of heat shock protein 70, postmortem metabolism and meat quality.
The expression of HSF3 and HSP70 mRNA in two chicken breeds exhibit species-specific and tissue-specific differences during heat stress.
Title: Alteration of HSF3 and HSP70 mRNA expression in the tissues of two chicken breeds during acute heat stress.
The effects of daily corticosterone injections on acute phase proteins (APP), IL-6, and HSP70 are reported; APP and HSP70 may be of value as indicators of stress in poultry.
Title: Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone.
Mn had a dosage-dependent effect on HSP27, HSP40, HSP60, HSP70, and HSP90 mRNA expression in chicken spleen lymphocytes in vitro.
Title: The effect of manganese-induced cytotoxicity on mRNA expressions of HSP27, HSP40, HSP60, HSP70 and HSP90 in chicken spleen lymphocytes in vitro.
Results of this study indicated a long-term enhancement of Hsp70 gene expression associated with improved thermotolerance acquisition in treated chicks without adversely affecting performance.
Title: Thermal manipulation during chicken embryogenesis results in enhanced Hsp70 gene expression and the acquisition of thermotolerance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info	PubMed
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables misfolded protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to unfolded protein	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein refolding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: heat shock 70 kDa protein

Names: dnaK-type molecular chaperone; heat shock 70kDa protein 2; heat shock protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006685.2 → NP_001006686.2 heat shock 70 kDa protein

Status: VALIDATED

Source sequence(s)

JAENSK010000215

UniProtKB/TrEMBL

B6EAX2, Q7SX63

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

52384623..52386942 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

52363374..52365693 complement

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GenBank, FASTA, Sequence Viewer (Graphics)