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SEL1L SEL1L ERAD E3 ligase adaptor subunit [ Gallus gallus (chicken) ]

Gene ID: 423391, updated on 13-Apr-2026
Symbol
SEL1Lprovided by CGNC
Full Name
SEL1L ERAD E3 ligase adaptor subunitprovided by CGNC
Primary source
CGNC:8035
See related
Ensembl:ENSGALG00010006847
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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See SEL1L in Genome Data Viewer
Location:
chromosome: 5
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (40445964..40476682, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (40423661..40454320, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111039 Neighboring gene general transcription factor IIA subunit 1 Neighboring gene uncharacterized LOC121111041 Neighboring gene stonin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC107053527

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation. Sugimoto T, et al. Cell Struct Funct, 2017 Jul 4. PMID 28552883
  2. SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line. Ninagawa S, et al. Cell Struct Funct, 2011. PMID 21857145
  3. The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein. Horimoto S, et al. J Biol Chem, 2013 Nov 1. PMID 24043630, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The SEL1L-dependent substrates require Derlin2/3 and Herp1/2 regardless of their soluble or transmembrane nature.
    Title: SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation.
  2. ATF6 represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature.
    Title: The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein.
  3. Chicken SEL1L was required for ERAD of misfolded luminal proteins such as glycosylated NHK and unglycosylated NHK-QQQ but dispensable for that of misfolded transmembrane proteins such as NHK(BACE) and CD3-delta, as in mammals.
    Title: SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
protein sel-1 homolog 1
Names
sel-1 suppressor of lin-12-like

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    40445964..40476682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040702156.2 → XP_040558090.1  protein sel-1 homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XTH6
    Conserved Domains (3) summary
    smart00059
    Location:118 → 166
    FN2; Fibronectin type 2 domain
    COG0790
    Location:417 → 693
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:391 → 420
    SLR; SLR repeat [structural motif]

  2. XM_421303.8 → XP_421303.3  protein sel-1 homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XTH6
    Related
    ENSGALP00010009291.1, ENSGALT00010016262.1
    Conserved Domains (3) summary
    smart00059
    Location:118 → 166
    FN2; Fibronectin type 2 domain
    COG0790
    Location:417 → 694
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:391 → 420
    SLR; SLR repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    40423661..40454320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040673976.2 → XP_040529910.1  protein sel-1 homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XTH6
    Conserved Domains (3) summary
    smart00059
    Location:118 → 166
    FN2; Fibronectin type 2 domain
    COG0790
    Location:417 → 693
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:391 → 420
    SLR; SLR repeat [structural motif]

  2. XM_040673975.2 → XP_040529909.1  protein sel-1 homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XTH6
    Conserved Domains (3) summary
    smart00059
    Location:118 → 166
    FN2; Fibronectin type 2 domain
    COG0790
    Location:417 → 694
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:391 → 420
    SLR; SLR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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