Format

Send to:

Choose Destination

DDB2 damage specific DNA binding protein 2 [ Gallus gallus (chicken) ]

Gene ID: 423185, updated on 23-May-2018
Symbol
DDB2provided by CGNC
Full Name
damage specific DNA binding protein 2provided by CGNC
Primary source
CGNC:6228
See related
Ensembl:ENSGALG00000008218
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
See DDB2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 5 NC_006092.5 (23388043..23430338, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 5 NC_006092.4 (23152841..23201779, complement)

Chromosome 5 - NC_006092.5Genomic Context describing neighboring genes Neighboring gene MAP kinase activating death domain Neighboring gene microRNA 6603 Neighboring gene nuclear receptor subfamily 1 group H member 3 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene chromosome 5 C11orf49 homolog Neighboring gene ADP ribosylation factor GTPase activating protein 2 Neighboring gene LDL receptor related protein 4

  • Cul4-DDB1-DDB2 complex, organism-specific biosystem (from KEGG)
    Cul4-DDB1-DDB2 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
  • Cul4-DDB1-DDB2 complex, conserved biosystem (from KEGG)
    Cul4-DDB1-DDB2 complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
  • Nucleotide excision repair, organism-specific biosystem (from KEGG)
    Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
  • Nucleotide excision repair, conserved biosystem (from KEGG)
    Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CONTRIBUTES_TO damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
CONTRIBUTES_TO ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
UV-damage excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UV-damage excision repair IEA
Inferred from Electronic Annotation
more info
 
histone H2A monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H2A monoubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
pyrimidine dimer repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyrimidine dimer repair IEA
Inferred from Electronic Annotation
more info
 
response to UV IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to UV-B IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Cul4B-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul4B-RING E3 ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
DNA damage-binding protein 2
Names
damage-specific DNA binding protein 2, 48kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039301.1NP_001034390.1  DNA damage-binding protein 2

    See identical proteins and their annotated locations for NP_001034390.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ720417
    UniProtKB/Swiss-Prot
    Q5ZJL7
    Related
    ENSGALP00000013362.3, ENSGALT00000013377.3
    Conserved Domains (3) summary
    COG2319
    Location:86458
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:127167
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:116440
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006092.5 Reference GRCg6a Primary Assembly

    Range
    23388043..23430338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015287020.2XP_015142506.1  DNA damage-binding protein 2 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:206571
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:248287
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:236553
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_015287023.2XP_015142509.1  DNA damage-binding protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q5ZJL7
    Conserved Domains (3) summary
    COG2319
    Location:86458
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:127167
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:116440
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_015287022.2XP_015142508.1  DNA damage-binding protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q5ZJL7
    Conserved Domains (3) summary
    COG2319
    Location:86458
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:127167
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:116440
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_025150707.1XP_025006475.1  DNA damage-binding protein 2 isoform X2

  5. XM_015287024.2XP_015142510.1  DNA damage-binding protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q5ZJL7
    Conserved Domains (3) summary
    COG2319
    Location:86458
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:127167
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:116440
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Support Center