DLC1 DLC1 Rho GTPase activating protein [Gallus gallus (chicken)] - Gene

Summary

Symbol: DLC1provided by CGNC
Full Name: DLC1 Rho GTPase activating proteinprovided by CGNC
Primary source: CGNC:10268
See related: Ensembl:ENSGALG00010014171
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 4

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (63845674..64105871)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (63829349..64089620)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOX9/SOX10-NEDD9/DLC1-RHOA regulatory axis governs neural crest cell migratory polarization
Title: Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: rho GTPase-activating protein 7

Names: deleted in liver cancer 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

63845674..64105871

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046940463.1 → XP_046796419.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5
XM_420693.8 → XP_420693.3 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5, A0A8V0YN25

Related

ENSGALP00010020035.1, ENSGALT00010034093.1

Conserved Domains (3) summary

cd08908
Location:1319 → 1522

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:455 → 514

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1075 → 1293

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_046940464.1 → XP_046796420.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5
XM_040699460.2 → XP_040555394.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5, A0A8V0YN25

Conserved Domains (3) summary

cd08908
Location:1319 → 1522

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:455 → 514

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1075 → 1293

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_040699458.2 → XP_040555392.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5, A0A8V0YN25

Conserved Domains (3) summary

cd08908
Location:1319 → 1522

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:455 → 514

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1075 → 1293

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_040699459.2 → XP_040555393.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5, A0A8V0YN25

Conserved Domains (3) summary

cd08908
Location:1319 → 1522

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:455 → 514

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1075 → 1293

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_046940465.1 → XP_046796421.1 rho GTPase-activating protein 7 isoform X3
XM_040699461.2 → XP_040555395.1 rho GTPase-activating protein 7 isoform X3

UniProtKB/TrEMBL

A0A8V0YGM9

Conserved Domains (3) summary

cd08908
Location:879 → 1082

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:15 → 74

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:635 → 853

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_004936009.5 → XP_004936066.1 rho GTPase-activating protein 7 isoform X2

UniProtKB/TrEMBL

A0A1D5PBM9, A0A8V0YGM9

Related

ENSGALP00010020028.1, ENSGALT00010034080.1

Conserved Domains (3) summary

cd08908
Location:907 → 1110

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:43 → 102

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:663 → 881

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_004936011.5 → XP_004936068.1 rho GTPase-activating protein 7 isoform X4

UniProtKB/TrEMBL

A0A8V0YGM9, F1P3K3

Related

ENSGALP00010020026.1, ENSGALT00010034075.1

Conserved Domains (3) summary

cd08908
Location:873 → 1076

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:9 → 68

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:629 → 847

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

63829349..64089620

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040670309.2 → XP_040526243.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5, A0A8V0YN25

Conserved Domains (3) summary

cd08908
Location:1319 → 1522

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:455 → 514

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1075 → 1293

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_046916810.1 → XP_046772766.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5
XM_040670308.2 → XP_040526242.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5, A0A8V0YN25

Conserved Domains (3) summary

cd08908
Location:1319 → 1522

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:455 → 514

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1075 → 1293

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_046916811.1 → XP_046772767.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5
XM_040670311.2 → XP_040526245.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5, A0A8V0YN25

Conserved Domains (3) summary

cd08908
Location:1319 → 1522

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:455 → 514

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1075 → 1293

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_040670310.2 → XP_040526244.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A1D5PEQ5, A0A8V0YN25

Conserved Domains (3) summary

cd08908
Location:1319 → 1522

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:455 → 514

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1075 → 1293

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_046916812.1 → XP_046772768.1 rho GTPase-activating protein 7 isoform X3
XM_040670314.2 → XP_040526248.1 rho GTPase-activating protein 7 isoform X3

UniProtKB/TrEMBL

A0A8V0YGM9

Conserved Domains (3) summary

cd08908
Location:879 → 1082

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:15 → 74

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:635 → 853

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_040670313.2 → XP_040526247.1 rho GTPase-activating protein 7 isoform X2

UniProtKB/TrEMBL

A0A1D5PBM9, A0A8V0YGM9

Conserved Domains (3) summary

cd08908
Location:907 → 1110

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:43 → 102

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:663 → 881

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_040670315.2 → XP_040526249.1 rho GTPase-activating protein 7 isoform X4

UniProtKB/TrEMBL

A0A8V0YGM9, F1P3K3

Conserved Domains (3) summary

cd08908
Location:873 → 1076

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:9 → 68

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:629 → 847

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...