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Mekk1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42253, updated on 26-Aug-2021

Summary

Official Symbol
Mekk1provided by FlyBase
Primary source
FLYBASE:FBgn0024329
Locus tag
Dmel_CG7717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7717; D-Mekk1; D-MEKK1; dMEKK; dMekk1; dMEKK1; dMEKK4; Dmel\CG7717; DmMEKK1; MEKK; mekk1; MEKK1; Mekk1/4; mekk1a; mekk1b; MEKK4
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Genomic context

See Mekk1 in Genome Data Viewer
Location:
91C5-91C5; 3-64 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18733106..18743594, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14558828..14569316, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Choline acetyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene greatwall

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular hyperosmotic salinity response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to arsenic-containing substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mucosal immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell size IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
Mekk1
Names
CG7717-PB
CG7717-PD
Mekk1-PB
Mekk1-PD
NP_650750.4
NP_732373.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18733106..18743594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169833.2NP_732373.1  Mekk1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732373.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSQ4
    Related
    FBpp0083099, FBtr0083684
    Conserved Domains (2) summary
    smart00220
    Location:12821541
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:12811542
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4
  2. NM_142493.3NP_650750.4  Mekk1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650750.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VE37
    Related
    FBpp0303771, FBtr0331353
    Conserved Domains (2) summary
    smart00220
    Location:11891448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:11881449
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4
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