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MEOX2 mesenchyme homeobox 2 [ Homo sapiens (human) ]

Gene ID: 4223, updated on 1-Jun-2020

Summary

Official Symbol
MEOX2provided by HGNC
Official Full Name
mesenchyme homeobox 2provided by HGNC
Primary source
HGNC:HGNC:7014
See related
Ensembl:ENSG00000106511 MIM:600535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAX; MOX2
Summary
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 25.8), fat (RPKM 23.2) and 13 other tissues See more
Orthologs

Genomic context

See MEOX2 in Genome Data Viewer
Location:
7p21.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (15611212..15686683, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (15650837..15726308, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIA pseudogene 5 Neighboring gene alkylglycerol monooxygenase Neighboring gene Sharpr-MPRA regulatory region 14752 Neighboring gene uncharacterized LOC105375166 Neighboring gene long intergenic non-protein coding RNA 2587 Neighboring gene ribosomal protein L36a pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood circulation TAS
Traceable Author Statement
more info
PubMed 
limb development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
somite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somite specification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein MOX-2
Names
growth arrest-specific homeobox

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032988.1 RefSeqGene

    Range
    5001..80472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005924.5NP_005915.2  homeobox protein MOX-2

    See identical proteins and their annotated locations for NP_005915.2

    Status: REVIEWED

    Source sequence(s)
    BC017021, BQ025060, DA586635
    Consensus CDS
    CCDS34605.1
    UniProtKB/Swiss-Prot
    P50222
    Related
    ENSP00000262041.5, ENST00000262041.6
    Conserved Domains (2) summary
    COG5576
    Location:160284
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam00046
    Location:191243
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    15611212..15686683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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