MED17 Mediator complex subunit 17 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: MED17provided by FlyBase
Official Full Name: Mediator complex subunit 17provided by FlyBase
Primary source: FLYBASE:FBgn0038578
Locus tag: Dmel_CG7957
See related: AllianceGenome:FB:FBgn0038578
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7957; dMED17; Dmel\CG7957; dTrap80; dTRAP80; dTRAP80/SRB4; l(3)s2956; Med17; p70; Trap80; TRAP80
Summary: Enables DNA-binding transcription factor binding activity and transcription coregulator activity. Contributes to transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II and sex comb development. Located in nucleus and pericentric heterochromatin. Part of mediator complex. Is expressed in several structures, including anterior endoderm anlage; embryonic brain; extended germ band embryo; germ layer; and spermatozoon. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18189072..18191265)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14014794..14016987)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription initiation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sex comb development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of core mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IEA Inferred from Electronic Annotation more info
part_of mediator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of pericentric heterochromatin	IPI Inferred from Physical Interaction more info	PubMed