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TCF21 transcription factor 21 [ Gallus gallus (chicken) ]

Gene ID: 421697, updated on 13-Apr-2026
Symbol
TCF21provided by CGNC
Full Name
transcription factor 21provided by CGNC
Primary source
CGNC:66408
See related
Ensembl:ENSGALG00010006187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See TCF21 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (55955807..55958287, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (55864085..55866564, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 12 Neighboring gene TATA-box binding protein like 1 Neighboring gene uncharacterized LOC121110364 Neighboring gene uncharacterized LOC112532169

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A. Zhang X, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872001
  2. Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Braitsch CM, et al. Dev Biol, 2012 Aug 15. PMID 22687751, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A.
    Title: Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A.
  2. Data show that all-trans-retinoic acid (RA) inhibition leads to decreased Pod1/Tcf21 expression in intact heart.
    Title: Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
transcription factor 21

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277711.2 → NP_001264640.1  transcription factor 21

    See identical proteins and their annotated locations for NP_001264640.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    R4GLC9
    Conserved Domains (1) summary
    cd19704
    Location:77 → 140
    bHLH_TS_TCF21_capsulin; basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    55955807..55958287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938859.1 → XP_046794815.1  transcription factor 21 isoform X2

  2. XM_046938857.1 → XP_046794813.1  transcription factor 21 isoform X1

    UniProtKB/TrEMBL
    R4GLC9
    Related
    ENSGALP00010008680.1, ENSGALT00010014730.1

  3. XM_046938858.1 → XP_046794814.1  transcription factor 21 isoform X1

    UniProtKB/TrEMBL
    R4GLC9

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    55864085..55866564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913991.1 → XP_046769947.1  transcription factor 21 isoform X2

  2. XM_046913989.1 → XP_046769945.1  transcription factor 21 isoform X1

    UniProtKB/TrEMBL
    R4GLC9

  3. XM_046913990.1 → XP_046769946.1  transcription factor 21 isoform X1

    UniProtKB/TrEMBL
    R4GLC9
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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