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htl heartless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42160, updated on 26-Aug-2021

Summary

Official Symbol
htlprovided by FlyBase
Official Full Name
heartlessprovided by FlyBase
Primary source
FLYBASE:FBgn0010389
Locus tag
Dmel_CG7223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7223; CT22273; CT39172; DFGF-R1; DFGF-R2; Dfr-1; DFR-1; Dfr1; DFR1; DFR1/DFGF-R2; Dmel\CG7223; DmHD-38; DPR3; dtk1; Dtk1; DTRK(FR1); EMS2; FGF-R2; FGFR; FGFR2; Fr1; FR1; HD-38; Htl; HTL/FGFR1; i100; i150; i79; j372; Tk1
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Genomic context

See htl in Genome Data Viewer
Location:
90E2-90E2; 3-62 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18045216..18052984, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13870938..13878706, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glycine-TCC 1-3 Neighboring gene stripe

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cardioblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in endodermal cell fate determination IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gonadal mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in larval visceral muscle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph gland crystal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph gland plasmatocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesodermal cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesodermal cell fate determination IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myoblast fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myotube cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of Rho guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pericardial nephrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pole cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of innate immune response HMP PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in salivary gland development TAS
Traceable Author Statement
more info
PubMed 
involved_in somatic muscle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ventral cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in visceral muscle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynapse of neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
heartless
Names
CG7223-PA
CG7223-PB
CG7223-PC
FGF receptor
fibroblast growth factor receptor
fibroblast growth factor receptor 1
htl-PA
htl-PB
htl-PC
NP_524394.2
NP_732286.1
NP_732287.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18045216..18052984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079670.3NP_524394.2  heartless, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524394.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07407
    Related
    FBpp0082970, FBtr0083548
    Conserved Domains (4) summary
    smart00221
    Location:416688
    STYKc; Protein kinase; unclassified specificity
    smart00410
    Location:113191
    IG_like; Immunoglobulin like
    cl11960
    Location:112191
    Ig; Immunoglobulin domain
    cl21453
    Location:404692
    PKc_like; Protein Kinases, catalytic domain
  2. NM_169785.2NP_732287.1  heartless, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732287.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07407
    Related
    FBpp0082972, FBtr0083550
    Conserved Domains (4) summary
    smart00221
    Location:416688
    STYKc; Protein kinase; unclassified specificity
    smart00410
    Location:113191
    IG_like; Immunoglobulin like
    cl11960
    Location:112191
    Ig; Immunoglobulin domain
    cl21453
    Location:404692
    PKc_like; Protein Kinases, catalytic domain
  3. NM_169784.2NP_732286.1  heartless, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732286.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07407
    Related
    FBpp0082971, FBtr0083549
    Conserved Domains (4) summary
    smart00221
    Location:416688
    STYKc; Protein kinase; unclassified specificity
    smart00410
    Location:113191
    IG_like; Immunoglobulin like
    cl11960
    Location:112191
    Ig; Immunoglobulin domain
    cl21453
    Location:404692
    PKc_like; Protein Kinases, catalytic domain
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