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MLH1 mutL homolog 1 [ Gallus gallus (chicken) ]

Gene ID: 420729, updated on 16-Jun-2026
Symbol
MLH1provided by CGNC
Full Name
mutL homolog 1provided by CGNC
Primary source
CGNC:9143
See related
Ensembl:ENSGALG00010016109
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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See MLH1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (45936769..45956855)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (45984438..46004523)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene doublecortin like kinase 3 Neighboring gene tetratricopeptide repeat and ankyrin repeat containing 1 Neighboring gene STARD3 N-terminal like Neighboring gene uncharacterized LOC121112221

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MutLalpha complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
DNA mismatch repair protein Mlh1
Names
DNA mismatch repair protein MLH1
MutL protein homolog 1
mutL homolog 1, colon cancer, nonpolyposis type 2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    45936769..45956855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_418828.6 → XP_418828.1  DNA mismatch repair protein Mlh1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P146, A0A8V0YUV7
    Related
    ENSGALP00010022391.1, ENSGALT00010038721.1
    Conserved Domains (2) summary
    TIGR00585
    Location:6 → 315
    mutl; DNA mismatch repair protein MutL
    pfam16413
    Location:503 → 757
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus

  2. XM_015281693.3 → XP_015137179.1  DNA mismatch repair protein Mlh1 isoform X2

    Conserved Domains (2) summary
    cd03483
    Location:1 → 94
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    pfam16413
    Location:261 → 516
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus

RNA

  1. XR_003073649.3 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    45984438..46004523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040663865.2 → XP_040519799.1  DNA mismatch repair protein Mlh1 isoform X1

    Conserved Domains (2) summary
    COG0323
    Location:8 → 688
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
    TIGR00585
    Location:6 → 315
    mutl; DNA mismatch repair protein MutL

  2. XM_040663866.1 → XP_040519800.1  DNA mismatch repair protein Mlh1 isoform X2

    Conserved Domains (2) summary
    COG0323
    Location:2 → 447
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
    cd03483
    Location:1 → 94
    MutL_Trans_MLH1; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in ...

RNA

  1. XR_005846488.2 RNA Sequence

  2. XR_005846489.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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