GHRHR growth hormone releasing hormone receptor [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: GHRHRprovided by CGNC
Official Full Name: growth hormone releasing hormone receptorprovided by CGNC
Primary source: CGNC:51246
See related: Ensembl:ENSGALG00010027343
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (1187466..1206029)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (1187584..1205962)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Three novel single nucleotide polymorphisms (SNPs) occur in the promoter region of the growth hormone-releasing hormone receptor gene. These SNPs have significant effects on chicken body weight, age of first egg, and egg number at various weeks of age.
Title: Single-nucleotide polymorphisms in the promoter of the growth hormone-releasing hormone receptor gene are associated with growth and reproduction traits in chickens.
Our findings not only suggest that cGHRHR variants may play a role in controlling normal pituitary functions, but also support that Asp(56) is nonessential for receptor activation and direct ligand-receptor interaction.
Title: Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand receptor interaction.
differential expressions of GHRH, GHRHR, and GH in the developing embryonic pituitaries imply that pituitary-derived GHRH and GHRHR may have a paracrine/autocrine role in the expansion of undifferentiated somatotroph precursor cells
Title: Expression profiles of growth hormone-releasing hormone and growth hormone-releasing hormone receptor during chicken embryonic pituitary development.
GHRH, perhaps together with GHRH-like peptide (chicken/carp-like), may function as the authentic endogenous ligands of GHRHR in chicken as well as in other lower vertebrate species
Title: Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor: evidence for a separate gene encoding GHRH in submammalian vertebrates.
adrenal glucocorticoids may substantially impact pituitary GH responses to GHRH in the chicken through modulation of GHRH-R gene expression
Title: Identification of the chicken growth hormone-releasing hormone receptor (GHRH-R) mRNA and gene: regulation of anterior pituitary GHRH-R mRNA levels by homologous and heterologous hormones.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth hormone-releasing hormone receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: growth hormone-releasing hormone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037834.2 → NP_001032923.1 growth hormone-releasing hormone receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_001032923.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

DQ114791, DQ230840, DQ284530

UniProtKB/TrEMBL

A0A8V1A8Q9, Q309X7

Related

ENSGALP00010040565.1, ENSGALT00010066299.1

Conserved Domains (3) summary

pfam02793
Location:48 → 109

HRM; Hormone receptor domain

cd14964
Location:126 → 150

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:123 → 390

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001201396.1 → NP_001188325.1 growth hormone-releasing hormone receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001188325.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.

Source sequence(s)

BM490642, DQ114791, DQ230840, DQ284530, DQ451550

UniProtKB/TrEMBL

A0A8V1A8Q9, Q1PCF1

Related

ENSGALP00010040573.1, ENSGALT00010066307.1

Conserved Domains (2) summary

pfam00002
Location:87 → 333

7tm_2; 7 transmembrane receptor (Secretin family)

cl02422
Location:49 → 73

HRM; Hormone receptor domain