U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AZIN1 antizyme inhibitor 1 [ Gallus gallus (chicken) ]

Gene ID: 420254, updated on 3-Jun-2026
Official Symbol
AZIN1provided by CGNC
Official Full Name
antizyme inhibitor 1provided by CGNC
Primary source
CGNC:11995
See related
Ensembl:ENSGALG00010012061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
OAZIN
Summary
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See AZIN1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (128819135..128844711, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (129026060..129051620, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109679 Neighboring gene Kruppel-like factor 10 Neighboring gene uncharacterized LOC121113120 Neighboring gene ATPase H+ transporting V1 subunit C1 Neighboring gene brain and acute leukemia, cytoplasmic

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Gene expression profiling of chicken primordial germ cell ESTs. Han JY, et al. BMC Genomics, 2006 Aug 30. PMID 16939661, Free PMC Article
  2. Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor. Kahana C. Essays Biochem, 2009 Nov 4. PMID 20095969
  3. ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels. Savolainen P, et al. Cytogenet Genome Res, 2005. PMID 16093725
  4. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  5. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ornithine decarboxylase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ornithine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of polyamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
antizyme inhibitor 1
Names
ornithine decarboxylase antizyme inhibitor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008729.2 → NP_001008729.1  antizyme inhibitor 1

    Status: REVIEWED

    Source sequence(s)
    AJ720630, BU350527, BU463028, CN226049, DR414120, DR431376
    UniProtKB/TrEMBL
    A0A1D5PIE4, A0A8V0YCI5
    Related
    ENSGALP00010016656.1, ENSGALT00010028897.1
    Conserved Domains (1) summary
    cd06831
    Location:26 → 421
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    128819135..128844711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046920532.1 → XP_046776488.1  antizyme inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PIE4, A0A8V0YCI5
    Related
    ENSGALP00010016652.1, ENSGALT00010028893.1

  2. XM_040678624.2 → XP_040534558.1  antizyme inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PIE4, A0A8V0YCI5
    Conserved Domains (1) summary
    cd06831
    Location:26 → 421
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

  3. XM_046920536.1 → XP_046776492.1  antizyme inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PIE4, A0A8V0YCI5

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    129026060..129051620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910725.1 → XP_046766681.1  antizyme inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PIE4, A0A8V0YCI5

  2. XM_046910724.1 → XP_046766680.1  antizyme inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PIE4, A0A8V0YCI5

  3. XM_046910726.1 → XP_046766682.1  antizyme inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PIE4, A0A8V0YCI5
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials