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INSR insulin receptor [ Gallus gallus (chicken) ]

Gene ID: 420133, updated on 3-Dec-2024
Symbol
INSRprovided by CGNC
Full Name
insulin receptorprovided by CGNC
Primary source
CGNC:2614
See related
Ensembl:ENSGALG00010027254
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CTK-1
Orthologs
human mouse all
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See INSR in Genome Data Viewer
Location:
chromosome: 28
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 28 NC_052559.1 (4561063..4599420, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 28 NC_052600.1 (4123210..4161611, complement)

Chromosome 28 - NC_052559.1Genomic Context describing neighboring genes Neighboring gene ectoderm-neural cortex protein 1-like Neighboring gene Rho guanine nucleotide exchange factor 18 Neighboring gene uncharacterized LOC124417446 Neighboring gene uncharacterized LOC121107760 Neighboring gene unconventional SNARE in the ER 1 Neighboring gene myosin IXB Neighboring gene HAUS augmin like complex subunit 8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The tyrosine kinase activity of the chicken insulin receptor is similar to that of the human insulin receptor. Kato H, et al. Biosci Biotechnol Biochem, 2000 Apr. PMID 10830518
  2. Insulin, insulin-like growth factor-1, insulin receptor, and insulin-like growth factor-1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus. Penha AM, et al. Mol Vis, 2011. PMID 21655358, Free PMC Article
  3. Genes for the insulin receptor and the insulin-like growth factor I receptor are expressed in the chicken embryo blastoderm and throughout organogenesis. Scavo LM, et al. Biochem Biophys Res Commun, 1991 May 15. PMID 1710113
  4. Effect of nutritional state on the formation of a complex involving insulin receptor IRS-1, the 52 kDa Src homology/collagen protein (Shc) isoform and phosphatidylinositol 3'-kinase activity. Dupont J, et al. Biochem J, 1998 Oct 15. PMID 9761726, Free PMC Article
  5. Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis. de la Rosa EJ, et al. Proc Natl Acad Sci U S A, 1998 Aug 18. PMID 9707581, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The differential regulation of insulin receptor and insulin-like growth factor-1 receptor in the the retinal pigment epithelium (RPE), choroid, and fibrous sclera is consistent with their involvement in a signaling cascade for emmetropization.
    Title: Insulin, insulin-like growth factor-1, insulin receptor, and insulin-like growth factor-1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
insulin receptor
Names
insulin receptor tyrosine kinase
tyrosine kinase
XP_001233399.3
XP_040509734.1
XP_040548888.1
XP_040548889.1
XP_046760673.1
XP_046760674.1
XP_046789947.1
XP_046789948.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4561063..4599420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001233398.7 → XP_001233399.3  insulin receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V1A390, A0A8V1AFM7
    Related
    ENSGALP00010040349.1, ENSGALT00010066083.1
    Conserved Domains (5) summary
    cd05061
    Location:987 → 1274
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:838 → 921
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:171 → 327
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:348 → 459
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:917 → 963
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_046904717.1 → XP_046760673.1  insulin receptor isoform X3

    UniProtKB/TrEMBL
    A0A8V1A390

  3. XM_040653800.2 → XP_040509734.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A1D5P6T3, A0A8V1A390
    Related
    ENSGALP00010040348.1, ENSGALT00010066082.1
    Conserved Domains (4) summary
    cd05061
    Location:958 → 1245
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    pfam03302
    Location:176 → 303
    VSP; Giardia variant-specific surface protein
    cd00063
    Location:809 → 892
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:197 → 244
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

  4. XM_046904718.1 → XP_046760674.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A1D5P6T3, A0A8V1A390
    Related
    ENSGALP00010040345.1, ENSGALT00010066079.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052600.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4123210..4161611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040692954.2 → XP_040548888.1  insulin receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V1A390, A0A8V1AFM7
    Conserved Domains (5) summary
    cd05061
    Location:987 → 1274
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:838 → 921
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:171 → 327
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:348 → 459
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:917 → 963
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_046933991.1 → XP_046789947.1  insulin receptor isoform X3

    UniProtKB/TrEMBL
    A0A8V1A390

  3. XM_040692955.2 → XP_040548889.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A1D5P6T3, A0A8V1A390
    Conserved Domains (4) summary
    cd05061
    Location:958 → 1245
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    pfam03302
    Location:176 → 303
    VSP; Giardia variant-specific surface protein
    cd00063
    Location:809 → 892
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:197 → 244
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

  4. XM_046933992.1 → XP_046789948.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A1D5P6T3, A0A8V1A390
Nucleotide Protein Strain
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