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INSR insulin receptor [ Gallus gallus (chicken) ]

Gene ID: 420133, updated on 20-Jun-2018

Summary

Symbol
INSRprovided by CGNC
Full Name
insulin receptorprovided by CGNC
Primary source
CGNC:2614
See related
Ensembl:ENSGALG00000040758
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CTK-1
Orthologs

Genomic context

See INSR in Genome Data Viewer
Location:
chromosome: 28
Exon count:
21
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 28 NC_006115.5 (4215002..4257792, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 28 NC_006115.4 (4129056..4167410, complement)

Chromosome 28 - NC_006115.5Genomic Context describing neighboring genes Neighboring gene ectoderm-neural cortex protein 1-like Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene uncharacterized LOC107055372 Neighboring gene unconventional SNARE in the ER 1 Neighboring gene myosin IXB

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • PI3K-Akt signaling, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • PI3K-Akt signaling, conserved biosystem (from KEGG)
    PI3K-Akt signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

General gene information

Markers

Homology

General protein information

Preferred Names
insulin receptor
Names
insulin receptor tyrosine kinase
tyrosine kinase
XP_001233399.3

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006115.5 Reference GRCg6a Primary Assembly

    Range
    4215002..4257792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001233398.5XP_001233399.3  insulin receptor

    UniProtKB/TrEMBL
    A0A1D5P6T3
    Related
    ENSGALP00000048413.1
    Conserved Domains (6) summary
    cd05061
    Location:9871274
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:838921
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:226273
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:171327
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:348459
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:9941261
    Pkinase_Tyr; Protein tyrosine kinase
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