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STK11 serine/threonine kinase 11 [ Gallus gallus (chicken) ]

Gene ID: 420105, updated on 3-Apr-2024

Summary

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Official Symbol
STK11provided by CGNC
Official Full Name
serine/threonine kinase 11provided by CGNC
Primary source
CGNC:1941
See related
Ensembl:ENSGALG00010028007
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
LKB1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 28
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 28 NC_052559.1 (3430150..3465263)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 28 NC_052600.1 (2999952..3035063)

Chromosome 28 - NC_052559.1Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 4 Neighboring gene strawberry notch homolog 2 Neighboring gene uncharacterized LOC121107748 Neighboring gene CACN beta subunit associated regulatory protein Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase. Blättler SM, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213310, Free PMC Article
  2. LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development. Creuzet SE, et al. Dev Biol, 2016 Oct 15. PMID 27527806
  3. Fasting alters protein expression of AMP-activated protein kinase in the hypothalamus of broiler chicks (Gallus gallus domesticus). Song Z, et al. Gen Comp Endocrinol, 2012 Sep 15. PMID 22771832
  4. Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. Lin-Marq N, et al. Mol Genet Genomics, 2005 Apr. PMID 15731909
  5. Characterization of the AMP-activated protein kinase pathway in chickens. Proszkowiec-Weglarz M, et al. Comp Biochem Physiol B Biochem Mol Biol, 2006 Jan. PMID 16343965

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of vesicle transport along microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase STK11
Names
liver kinase B1 homolog
serine/threonine-protein kinase 11
serine/threonine-protein kinase LKB1
NP_001039298.1
XP_015155418.2
XP_046789742.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045833.1 → NP_001039298.1  serine/threonine-protein kinase STK11

    See identical proteins and their annotated locations for NP_001039298.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ864976
    UniProtKB/Swiss-Prot
    Q0GGW5
    UniProtKB/TrEMBL
    A0A8V1AEH4
    Related
    ENSGALP00010041636.1, ENSGALT00010067893.1
    Conserved Domains (2) summary
    smart00220
    Location:49 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:55 → 309
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3430150..3465263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015299932.4 → XP_015155418.2  serine/threonine-protein kinase STK11 isoform X1

    UniProtKB/TrEMBL
    A0A8V1AGZ9
    Related
    ENSGALP00010041635.1, ENSGALT00010067892.1
    Conserved Domains (1) summary
    cd14119
    Location:55 → 309
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052600.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2999952..3035063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046933786.1 → XP_046789742.1  serine/threonine-protein kinase STK11 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0GGW5.1 GenPept UniProtKB/Swiss-Prot:Q0GGW5

Gene LinkOut

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