CD320 CD320 molecule [Gallus gallus (chicken)] - Gene

Summary

Symbol: CD320provided by CGNC
Full Name: CD320 moleculeprovided by CGNC
Primary source: CGNC:51172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: TVA
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	28	NC_052559.1 (1302511..1307560)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	28	NC_052600.1 (875524..880604)

Chromosome 28 - NC_052559.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that the chicken protein Tva serves as the specific receptor for the Avian leukosis virus subgroup K entry.
Title: The Novel Avian Leukosis Virus Subgroup K Shares Its Cellular Receptor with Subgroup A.
The heterozygote tva(s1/r1) and the resistant genotype tva(r2/r2), tva(r3/r3), and tva(r4/r4) were detected in Chinese chickens by direct sequencing. The resistant genotype tvb(r/r) was detected in JNBRC, CB07, CB12, CB14, and CB15 by pyrosequencing.
Title: Single nucleotide polymorphism variants within tva and tvb receptor genes in Chinese chickens.
Intronic deletions of the tva receptor gene decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A.
Title: Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A.
The Cys40Trp mutation of TVA confers resistance to ASLV(A) infection, whereas ASLV subtypes B and C were unaffected by the mutation. ASLV envelope protein-TVA binding affinities were determined for chicken and quail.
Title: Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: CD320 antigen

Names: Tva receptor; susceptibility to subgroup A viruses

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044645.3 → NP_001038110.3 CD320 antigen isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) has four exons.

Source sequence(s)

BI067620, BM427041, BM486807, JAENSK010000374
NM_001389405.2 → NP_001376334.2 CD320 antigen isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) has five exons.

Source sequence(s)

AY531258, BI067620, BM427041, BM486807, BU119771, JAENSK010000374

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

1302511..1307560

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040653527.1 → XP_040509461.1 CD320 antigen isoform X1

Conserved Domains (1) summary

cd00112
Location:89 → 128

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_046904572.1 → XP_046760528.1 CD320 antigen isoform X1
XM_040653529.1 → XP_040509463.1 CD320 antigen isoform X3

Conserved Domains (1) summary

cd00112
Location:89 → 128

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_040653528.2 → XP_040509462.2 CD320 antigen isoform X2