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Der-2 Derlin-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42005, updated on 6-Jul-2021

Summary

Official Symbol
Der-2provided by FlyBase
Official Full Name
Derlin-2provided by FlyBase
Primary source
FLYBASE:FBgn0038438
Locus tag
Dmel_CG14899
Gene type
protein coding
RNA name
Derlin-2
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cg14899; CG14899; dDer-2; DER1; Dmel\CG14899
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Genomic context

See Der-2 in Genome Data Viewer
Location:
89B18-89B18; 3-58 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16482694..16484223, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12308416..12309945, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46029 Neighboring gene Guanylyl cyclase at 89Db Neighboring gene Succinate dehydrogenase assembly factor 3 Neighboring gene Dihydrofolate reductase Neighboring gene Cadherin 89D Neighboring gene Gustatory receptor 89a

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Der-2 gene: The Der-2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, mosquito, C.elegans, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-specific protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of Hrd1p ubiquitin ligase ERAD-L complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
Derlin-2
Names
CG14899-PA
Der-2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16482694..16484223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142296.3NP_650553.1  Derlin-2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEU2
    Related
    FBpp0082758, FBtr0083307
    Conserved Domains (1) summary
    pfam04511
    Location:11201
    DER1; Der1-like family
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