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ART4 ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) [ Homo sapiens (human) ]

Gene ID: 420, updated on 11-Jul-2021

Summary

Official Symbol
ART4provided by HGNC
Official Full Name
ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)provided by HGNC
Primary source
HGNC:HGNC:726
See related
Ensembl:ENSG00000111339 MIM:110600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DO; DOK1; ARTC4; CD297; DO/ART4
Summary
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 8.6), spleen (RPKM 7.9) and 11 other tissues See more
Orthologs
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Genomic context

See ART4 in Genome Data Viewer
Location:
12p12.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (14825569..14843526, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14978503..14996460, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 60 Neighboring gene WW domain binding protein 11 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene matrix Gla protein Neighboring gene endoplasmic reticulum protein 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in arginine metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in peptidyl-arginine ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ADP-ribosylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ecto-ADP-ribosyltransferase 4
Names
ADP-ribosyltransferase 4 (DO blood group)
ADP-ribosyltransferase 4 (Dombrock blood group)
ADP-ribosyltransferase C2 and C3 toxin-like 4
Do glycoprotein
Dombrock blood group carrier molecule
Dombrock glycoprotein
NAD(+)--protein-arginine ADP-ribosyltransferase 4
NAD(P)(+)--arginine ADP-ribosyltransferase 4
mono-ADP-ribosyltransferase 4
truncated Dombrock blood group protein
NP_001341575.1
NP_066549.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007477.2 RefSeqGene

    Range
    4954..22911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_807

mRNA and Protein(s)

  1. NM_001354646.2NP_001341575.1  ecto-ADP-ribosyltransferase 4 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007655, AI149009, AY829437
    Related
    ENSP00000405689.1, ENST00000420600.1
    Conserved Domains (1) summary
    cl00173
    Location:56277
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
  2. NM_021071.4NP_066549.2  ecto-ADP-ribosyltransferase 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_066549.2

    Status: REVIEWED

    Source sequence(s)
    AC007655, AF290204, BX096478, CR746266
    Consensus CDS
    CCDS8668.1
    UniProtKB/Swiss-Prot
    Q93070
    Related
    ENSP00000228936.4, ENST00000228936.6
    Conserved Domains (1) summary
    cl00173
    Location:56277
    VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    14825569..14843526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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