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ME1 malic enzyme 1 [ Homo sapiens (human) ]

Gene ID: 4199, updated on 11-Sep-2022

Summary

Official Symbol
ME1provided by HGNC
Official Full Name
malic enzyme 1provided by HGNC
Primary source
HGNC:HGNC:6983
See related
Ensembl:ENSG00000065833 MIM:154250; AllianceGenome:HGNC:6983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MES; HUMNDME
Summary
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 29.4), adrenal (RPKM 23.1) and 21 other tissues See more
Orthologs
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Genomic context

See ME1 in Genome Data Viewer
Location:
6q14.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83210402..83431051, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84433644..84654257, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83920121..84140770, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene DOP1 leucine zipper like protein A Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene serine protease 35 Neighboring gene synaptosome associated protein 91 Neighboring gene Sharpr-MPRA regulatory region 13924

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding TAS
Traceable Author Statement
more info
PubMed 
enables NAD binding TAS
Traceable Author Statement
more info
PubMed 
enables NADP binding TAS
Traceable Author Statement
more info
PubMed 
enables electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables malate dehydrogenase (decarboxylating) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables malic enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables malic enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables malic enzyme activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxaloacetate decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NADH metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in NADP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
 
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in malate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleotide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of NADP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to carbohydrate TAS
Traceable Author Statement
more info
PubMed 
involved_in response to hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NADP-dependent malic enzyme
Names
Malic enzyme, cytoplasmic
NADP-ME
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
malic enzyme 1, NADP(+)-dependent, cytosolic
malic enzyme 1, soluble
pyruvic-malic carboxylase
NP_002386.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002395.6NP_002386.1  NADP-dependent malic enzyme

    See identical proteins and their annotated locations for NP_002386.1

    Status: REVIEWED

    Source sequence(s)
    AL049699, BC025246, DA520723, KF458214
    Consensus CDS
    CCDS34492.1
    UniProtKB/Swiss-Prot
    P48163, Q9UIY4
    Related
    ENSP00000358719.3, ENST00000369705.4
    Conserved Domains (3) summary
    cd05312
    Location:270547
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:11551
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:79260
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    83210402..83431051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    84433644..84654257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)