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ME1 malic enzyme 1 [ Homo sapiens (human) ]

Gene ID: 4199, updated on 7-Dec-2018

Summary

Official Symbol
ME1provided by HGNC
Official Full Name
malic enzyme 1provided by HGNC
Primary source
HGNC:HGNC:6983
See related
Ensembl:ENSG00000065833 MIM:154250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MES; HUMNDME
Summary
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 29.4), adrenal (RPKM 23.1) and 21 other tissues See more
Orthologs

Genomic context

See ME1 in Genome Data Viewer
Location:
6q14.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (83210389..83431219, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83920108..84140938, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene DOP1 leucine zipper like protein A Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene serine protease 35 Neighboring gene synaptosome associated protein 91

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • NRF2 pathway, organism-specific biosystem (from WikiPathways)
    NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Pyruvate metabolism, organism-specific biosystem (from KEGG)
    Pyruvate metabolism, organism-specific biosystem
    Pyruvate metabolism
  • Pyruvate metabolism, conserved biosystem (from KEGG)
    Pyruvate metabolism, conserved biosystem
    Pyruvate metabolism
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding TAS
Traceable Author Statement
more info
PubMed 
NAD binding TAS
Traceable Author Statement
more info
PubMed 
NADP binding TAS
Traceable Author Statement
more info
PubMed 
electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
malate dehydrogenase (decarboxylating) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
malate dehydrogenase (decarboxylating) (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity TAS
Traceable Author Statement
more info
 
malic enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malic enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
malic enzyme activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NADP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
regulation of NADP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
response to carbohydrate TAS
Traceable Author Statement
more info
PubMed 
response to hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NADP-dependent malic enzyme
Names
Malic enzyme, cytoplasmic
NADP-ME
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
malic enzyme 1, NADP(+)-dependent, cytosolic
malic enzyme 1, soluble
pyruvic-malic carboxylase
NP_002386.1
XP_011534138.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002395.6NP_002386.1  NADP-dependent malic enzyme

    See identical proteins and their annotated locations for NP_002386.1

    Status: REVIEWED

    Source sequence(s)
    AL049699, BC025246, DA520723, KF458214
    Consensus CDS
    CCDS34492.1
    UniProtKB/Swiss-Prot
    P48163
    Related
    ENSP00000358719.3, ENST00000369705.3
    Conserved Domains (3) summary
    cd05312
    Location:270547
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:11551
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:79260
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    83210389..83431219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535836.3XP_011534138.1  NADP-dependent malic enzyme isoform X1

    See identical proteins and their annotated locations for XP_011534138.1

    UniProtKB/Swiss-Prot
    P48163
    Conserved Domains (3) summary
    cd05312
    Location:195472
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    COG0281
    Location:5474
    SfcA; Malic enzyme [Energy production and conversion]
    pfam00390
    Location:4185
    malic; Malic enzyme, N-terminal domain
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