HSD11B1B hydroxysteroid 11-beta dehydrogenase 1B [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: HSD11B1Bprovided by CGNC
Official Full Name: hydroxysteroid 11-beta dehydrogenase 1Bprovided by CGNC
Primary source: CGNC:937
See related: Ensembl:ENSGALG00010027206
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; HSD11B1; SDR26C1; 11-beta-HSD1
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Genomic context

Location:: chromosome: 26

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	26	NC_052557.1 (3187216..3190093)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	26	NC_052598.1 (3157531..3160408)

Chromosome 26 - NC_052557.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The substantial reduction of dehydrocorticosterone (A) into corticosterone (B) (but no conversion of B into A) found in the cytosol is most likely executed by a unidirectional soluble reductase, different than 11 betaHSD1.
Title: Distinct features of dehydrocorticosterone reduction into corticosterone in the liver and duodenum of the domestic fowl (Gallus gallus domesticus).

Submit: New GeneRIF Correction

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in steroid catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: corticosteroid 11-beta-dehydrogenase isozyme 1

Names: hydroxysteroid (11-beta) dehydrogenase 1; hydroxysteroid (11-beta) dehydrogenase 1b; short chain dehydrogenase/reductase family 26C, member 1

XP_040547675.1

EC 1.1.1.146

XP_417988.2

EC 1.1.1.146

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

3187216..3190093

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_417988.8 → XP_417988.2 corticosteroid 11-beta-dehydrogenase isozyme 1

UniProtKB/TrEMBL

E1BZ22

Related

ENSGALP00010040221.1, ENSGALT00010065955.1

Conserved Domains (2) summary

pfam00106
Location:35 → 223

adh_short; short chain dehydrogenase

cl21454
Location:32 → 278

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052598.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

3157531..3160408

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040691741.2 → XP_040547675.1 corticosteroid 11-beta-dehydrogenase isozyme 1

Conserved Domains (1) summary

cl21454
Location:32 → 278

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins