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BACE1 beta-secretase 1 [ Gallus gallus (chicken) ]

Gene ID: 419768, updated on 5-Mar-2024

Summary

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Official Symbol
BACE1provided by CGNC
Official Full Name
beta-secretase 1provided by CGNC
Primary source
CGNC:5516
See related
Ensembl:ENSGALG00010023208
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
BACE
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (5290701..5300963, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (5250985..5261249, complement)

Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene ring finger protein 214 Neighboring gene centrosomal protein 164 Neighboring gene DS cell adhesion molecule like 1 Neighboring gene microRNA 1667

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing. Carrodeguas JA, et al. Neuroscience, 2005. PMID 16039787

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-secretase 1
Names
beta-site APP cleaving enzyme
beta-site APP-cleaving enzyme 1
XP_015153722.1
XP_015153723.1
XP_015153724.1
XP_015153725.1
XP_040546211.1
XP_040546212.1
XP_040546213.1
XP_040546214.1
XP_040546215.1
XP_417908.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5290701..5300963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015298239.4 → XP_015153725.1  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  2. XM_015298238.4 → XP_015153724.1  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  3. XM_015298237.4 → XP_015153723.1  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  4. XM_015298236.4 → XP_015153722.1  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  5. XM_417908.8 → XP_417908.3  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Related
    ENSGALP00010034318.1, ENSGALT00010056576.1
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5250985..5261249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040690278.2 → XP_040546212.1  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  2. XM_040690281.2 → XP_040546215.1  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  3. XM_040690280.2 → XP_040546214.1  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  4. XM_040690279.2 → XP_040546213.1  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

  5. XM_040690277.2 → XP_040546211.1  beta-secretase 1

    UniProtKB/TrEMBL
    A0A1D5PSJ2, F1N916
    Conserved Domains (1) summary
    cd05473
    Location:68 → 431
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
Nucleotide Protein Strain
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