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ST14 suppression of tumorigenicity 14 [ Gallus gallus (chicken) ]

Gene ID: 419731, updated on 3-Apr-2024

Summary

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Symbol
ST14provided by CGNC
Full Name
suppression of tumorigenicity 14provided by CGNC
Primary source
CGNC:51075
See related
Ensembl:ENSGALG00010023375
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
27
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (1612151..1639305)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (1571818..1599011)

Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene PR domain 10 Neighboring gene nuclear factor related to kappaB binding protein Neighboring gene uncharacterized LOC124417384 Neighboring gene uncharacterized LOC121107517 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. Basel-Vanagaite L, et al. Am J Hum Genet, 2007 Mar. PMID 17273967, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acrosome reaction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
suppressor of tumorigenicity 14 protein
Names
suppression of tumorigenicity 14 (colon carcinoma)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1612151..1639305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046903840.1 → XP_046759796.1  suppressor of tumorigenicity 14 protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZUZ0

  2. XM_046903839.1 → XP_046759795.1  suppressor of tumorigenicity 14 protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZUZ0

  3. XM_046903845.1 → XP_046759801.1  suppressor of tumorigenicity 14 protein isoform X9

  4. XM_040652101.2 → XP_040508035.1  suppressor of tumorigenicity 14 protein isoform X2

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:426 → 530
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:610 → 644
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:701 → 938
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. XM_046903841.1 → XP_046759797.1  suppressor of tumorigenicity 14 protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZUZ0

  6. XM_040652100.2 → XP_040508034.1  suppressor of tumorigenicity 14 protein isoform X1

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:426 → 530
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:610 → 644
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:702 → 939
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  7. XM_046903838.1 → XP_046759794.1  suppressor of tumorigenicity 14 protein isoform X1

  8. XM_025143294.3 → XP_024999062.2  suppressor of tumorigenicity 14 protein isoform X3

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:347 → 451
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:531 → 565
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:623 → 860
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  9. XM_046903844.1 → XP_046759800.1  suppressor of tumorigenicity 14 protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZUZ0

  10. XM_004947983.5 → XP_004948040.2  suppressor of tumorigenicity 14 protein isoform X4

    UniProtKB/TrEMBL
    A0A8V1A0H6, A0A8V1A0I1
    Related
    ENSGALP00010034656.1, ENSGALT00010056988.1
    Conserved Domains (3) summary
    cd00041
    Location:332 → 436
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:516 → 550
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:608 → 845
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  11. XM_040652102.2 → XP_040508036.1  suppressor of tumorigenicity 14 protein isoform X5

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:332 → 436
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:516 → 550
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:607 → 844
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  12. XM_004947981.5 → XP_004948038.2  suppressor of tumorigenicity 14 protein isoform X6

    UniProtKB/TrEMBL
    A0A8V1A0H2, A0A8V1A0I1
    Related
    ENSGALP00010034651.1, ENSGALT00010056982.1
    Conserved Domains (3) summary
    cd00041
    Location:316 → 420
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:500 → 534
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:592 → 829
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  13. XM_040652103.2 → XP_040508037.1  suppressor of tumorigenicity 14 protein isoform X7

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:316 → 420
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:500 → 534
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:591 → 828
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  14. XM_046903843.1 → XP_046759799.1  suppressor of tumorigenicity 14 protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZUZ0

  15. XM_046903842.1 → XP_046759798.1  suppressor of tumorigenicity 14 protein isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZUZ0
    Related
    ENSGALP00010034664.1, ENSGALT00010057001.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1571818..1599011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046932473.1 → XP_046788429.1  suppressor of tumorigenicity 14 protein isoform X8

  2. XM_046932472.1 → XP_046788428.1  suppressor of tumorigenicity 14 protein isoform X8

  3. XM_046932478.1 → XP_046788434.1  suppressor of tumorigenicity 14 protein isoform X9

  4. XM_040690470.2 → XP_040546404.1  suppressor of tumorigenicity 14 protein isoform X2

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:426 → 530
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:610 → 644
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:701 → 938
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. XM_046932474.1 → XP_046788430.1  suppressor of tumorigenicity 14 protein isoform X8

  6. XM_040690469.2 → XP_040546403.1  suppressor of tumorigenicity 14 protein isoform X1

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:426 → 530
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:610 → 644
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:702 → 939
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  7. XM_046932471.1 → XP_046788427.1  suppressor of tumorigenicity 14 protein isoform X1

  8. XM_040690471.2 → XP_040546405.1  suppressor of tumorigenicity 14 protein isoform X3

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:347 → 451
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:531 → 565
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:623 → 860
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  9. XM_046932477.1 → XP_046788433.1  suppressor of tumorigenicity 14 protein isoform X8

  10. XM_040690475.2 → XP_040546409.1  suppressor of tumorigenicity 14 protein isoform X4

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:332 → 436
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:516 → 550
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:608 → 845
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  11. XM_040690472.2 → XP_040546406.1  suppressor of tumorigenicity 14 protein isoform X5

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:332 → 436
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:516 → 550
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:607 → 844
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  12. XM_040690473.2 → XP_040546407.1  suppressor of tumorigenicity 14 protein isoform X6

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:316 → 420
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:500 → 534
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:592 → 829
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  13. XM_040690474.2 → XP_040546408.1  suppressor of tumorigenicity 14 protein isoform X7

    UniProtKB/TrEMBL
    A0A8V1A0I1
    Conserved Domains (3) summary
    cd00041
    Location:316 → 420
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:500 → 534
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:591 → 828
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  14. XM_046932476.1 → XP_046788432.1  suppressor of tumorigenicity 14 protein isoform X8

  15. XM_046932475.1 → XP_046788431.1  suppressor of tumorigenicity 14 protein isoform X8

Nucleotide Protein
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