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Akt Akt kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41957, updated on 9-Dec-2024

Summary

Official Symbol
Aktprovided by FlyBase
Official Full Name
Akt kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0010379
Locus tag
Dmel_CG4006
See related
AllianceGenome:FB:FBgn0010379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
akt; AKT; Akt-1; AKT-1; Akt/PKB; AKT/PKB; akt1; Akt1; AKT1; CG4006; D-Akt; dakt; dAkt; dAKT; Dakt; DAkt; DAKT; dAKT/dPKB; dAkt/PKB; dakt1; dAkt1; dAKT1; Dakt1; DAkt1; DAKT1; DAKT1/PKB; Dkat1; Dmel\CG4006; dPKB; Dpkb; DPKB; DRAC-PK; DRAC-PK66; DRAC-PK85; l(3)04226; l(3)89Bq; p-Akt; P-Akt; P-AKT; pAkt; PBB; PKB; PKB/Akt; PKB/AKT; PKB/dAKT; RAC; RacPK
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of cell communication; and regulation of neuron projection development. Acts upstream of with a positive effect on regulation of growth and regulation of hemocyte proliferation. Located in several cellular components, including cell cortex; cytosol; and neuronal cell body. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Used to study Parkinson's disease; alcohol use disorder; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); colorectal cancer (multiple); glucose metabolism disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Akt in Genome Data Viewer
Location:
89B3-89B3; 3-58 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16099228..16105670)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11924950..11931392)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Myosin heavy chain-like Neighboring gene uncharacterized protein Neighboring gene sex-specific enzyme 2 Neighboring gene Stubble Neighboring gene MICOS subunit 26/27 Neighboring gene uncharacterized protein Neighboring gene 48 related 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_positive_effect multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of peptide hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of border follicle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipid storage IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of positive regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_positive_effect regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_positive_effect regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing, spreading of cells IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Akt kinase
Names
Akt-PA
Akt-PB
Akt-PC
Akt-PD
Akt-PE
Akt1
CG4006-PA
CG4006-PB
CG4006-PC
CG4006-PD
CG4006-PE
RAC serine/threonine protein kinase
dAkt kinase
protein kinase B
related to PKA to PKC protein kinases
related to the A and C kinases
NP_001287353.1
NP_001287354.1
NP_732113.3
  • non-AUG (ACG) translation initiation
NP_732114.1
NP_732115.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16099228..16105670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300425.1NP_001287354.1  Akt kinase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIA3, H1ZY63, H1ZY64
    Conserved Domains (4) summary
    smart00220
    Location:185442
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:24133
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05571
    Location:189509
    STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B
    pfam00169
    Location:26130
    PH; PH domain
  2. NM_169706.2NP_732114.1  Akt kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732114.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIA3, H1ZY63, H1ZY64
    Related
    FBpp0082681
    Conserved Domains (4) summary
    smart00220
    Location:185442
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:24133
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05571
    Location:189509
    STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B
    pfam00169
    Location:26130
    PH; PH domain
  3. NM_169707.2NP_732115.1  Akt kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732115.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIA3, H1ZY63, H1ZY64
    Related
    FBpp0082680
    Conserved Domains (4) summary
    smart00220
    Location:185442
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:24133
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05571
    Location:189509
    STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B
    pfam00169
    Location:26130
    PH; PH domain
  4. NM_169705.2NP_732113.3  Akt kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732113.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KI65, Q24293, Q24469, Q24470, Q7JN11, Q8INB9, Q8T9A5, Q9VEY7
    UniProtKB/TrEMBL
    H1ZY63
    Related
    FBpp0082682
    Conserved Domains (4) summary
    smart00220
    Location:266523
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:105214
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05571
    Location:270590
    STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B
    pfam00169
    Location:107211
    PH; PH domain
  5. NM_001300424.1NP_001287353.1  Akt kinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287353.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIA3, H1ZY63, H1ZY64
    Conserved Domains (4) summary
    smart00220
    Location:185442
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:24133
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05571
    Location:189509
    STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B
    pfam00169
    Location:26130
    PH; PH domain