CLCN6 chloride voltage-gated channel 6 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CLCN6provided by CGNC
Full Name: chloride voltage-gated channel 6provided by CGNC
Primary source: CGNC:3395
See related: Ensembl:ENSGALG00010017582
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	21	NC_052552.1 (5578073..5598557, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	21	NC_052593.1 (5612149..5632654, complement)

Chromosome 21 - NC_052552.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: H(+)/Cl(-) exchange transporter 6; chloride transport protein 6

Names: chloride channel 6; chloride channel, voltage-sensitive 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285979.2 → NP_001272908.1 H(+)/Cl(-) exchange transporter 6

Status: PROVISIONAL

Source sequence(s)

JAENSK010000329

UniProtKB/TrEMBL

A0A8V0Z261

Related

ENSGALP00010024995.1, ENSGALT00010042505.1

Conserved Domains (5) summary

smart00116
Location:607 → 654

CBS; Domain in cystathionine beta-synthase and other proteins

COG0517
Location:802 → 852

CBS; CBS domain [Signal transduction mechanisms]

cd03685
Location:47 → 587

ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...

cd04591
Location:697 → 852

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:138 → 569

Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

5578073..5598557 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040651189.1 → XP_040507123.1 chloride transport protein 6 isoform X1

UniProtKB/TrEMBL

A0A8V0Z261

Conserved Domains (3) summary

COG3448
Location:654 → 830

COG3448; CBS-domain-containing membrane protein [Signal transduction mechanisms]

cd03685
Location:23 → 563

ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...

cd04591
Location:575 → 831

CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria