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DNMT3B DNA methyltransferase 3 beta [ Gallus gallus (chicken) ]

Gene ID: 419287, updated on 5-Sep-2025
Symbol
DNMT3Bprovided by CGNC
Full Name
DNA methyltransferase 3 betaprovided by CGNC
Primary source
CGNC:50960
See related
Ensembl:ENSGALG00010013394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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See DNMT3B in Genome Data Viewer
Location:
chromosome: 20
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (10592207..10605914)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (10379581..10393263)

Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107345 Neighboring gene COMM domain containing 7 Neighboring gene microtubule associated protein RP/EB family member 1 Neighboring gene BPI fold containing family B member 3 Neighboring gene BPI fold containing family B member 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. DNA methyltransferase 3B regulates duration of neural crest production via repression of Sox10. Hu N, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25453070, Free PMC Article
  2. The methylation status of the embryonic limb skeletal progenitors determines their cell fate in chicken. Sanchez-Fernandez C, et al. Commun Biol, 2020 Jun 5. PMID 32504030, Free PMC Article
  3. Expression patterns and miRNA regulation of DNA methyltransferases in chicken primordial germ cells. Rengaraj D, et al. PLoS One, 2011 May 3. PMID 21559294, Free PMC Article
  4. An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines. Yu Y, et al. PLoS One, 2008 Jul 16. PMID 18648519, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In developing limbs, Dnmt3b exhibits well-defined gene expression patterns in regions destined to degenerate, such as interdigital tissues and prospective joint regions. Dnmt3b functional experiments revealed its role as a positive regulator of cell death and negative regulator of chondrogenesis in skeletal progenitors of the autopod.
    Title: The methylation status of the embryonic limb skeletal progenitors determines their cell fate in chicken.
  2. DNMT3B directly binds to and methylates the Sox10 promoter in neural tube progenitors, resulting in cessation of neural crest epithelial-to-mesenchymal transition.
    Title: DNA methyltransferase 3B regulates duration of neural crest production via repression of Sox10.
  3. analysis of expression patterns and miRNA regulation of DNA methyltransferases in chicken primordial germ cells
    Title: Expression patterns and miRNA regulation of DNA methyltransferases in chicken primordial germ cells.
  4. analysis of the potential of epigenetic alterations in DNMT1 and DNMT3a, as well as the DNA mutations in DNMT3b, as epigenetic and genetic factors to neoplastic diseases of chickens
    Title: An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
DNA (cytosine-5)-methyltransferase 3B
Names
DNA (cytosine-5-)-methyltransferase 3 beta
DNA cytosine-5 methyltransferase 3 beta
DNA methyltransferase HsaIIIB
NP_001019999.2
NP_001383769.1
NP_001383770.1
NP_001383771.1
NP_001383772.1
NP_001383773.1
XP_040506640.1
XP_040506643.1
XP_046758834.1
XP_046758835.1
XP_046758836.1
XP_046758837.1
XP_046786735.1
XP_046786736.1
XP_046786737.1
XP_046786738.1
XP_046786739.1
XP_046786740.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024828.4 → NP_001019999.2  DNA (cytosine-5)-methyltransferase 3B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000328
    UniProtKB/TrEMBL
    Q4W5Z3
    Conserved Domains (3) summary
    cd05835
    Location:237 → 323
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    cd11728
    Location:425 → 544
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
    cl30459
    Location:568 → 797
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

  2. NM_001396840.1 → NP_001383769.1  DNA (cytosine-5)-methyltransferase 3B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000328
    UniProtKB/TrEMBL
    Q4W5Z3
    Conserved Domains (3) summary
    cd05835
    Location:213 → 299
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    cd11728
    Location:401 → 520
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
    cl30459
    Location:544 → 773
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

  3. NM_001396841.1 → NP_001383770.1  DNA (cytosine-5)-methyltransferase 3B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000328
    UniProtKB/TrEMBL
    Q4W5Z3
    Conserved Domains (3) summary
    cd05835
    Location:237 → 323
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    cd11728
    Location:425 → 544
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
    cl30459
    Location:568 → 797
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

  4. NM_001396842.1 → NP_001383771.1  DNA (cytosine-5)-methyltransferase 3B isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000328
    UniProtKB/TrEMBL
    A0A8V0YS81
    Conserved Domains (3) summary
    cd05835
    Location:237 → 323
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    cd11728
    Location:425 → 544
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
    cl30459
    Location:568 → 760
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

  5. NM_001396843.1 → NP_001383772.1  DNA (cytosine-5)-methyltransferase 3B isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000328
    UniProtKB/TrEMBL
    A0A8V0YS81
    Conserved Domains (3) summary
    cd05835
    Location:237 → 323
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    cd11728
    Location:425 → 544
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
    cl30459
    Location:568 → 760
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

  6. NM_001396844.1 → NP_001383773.1  DNA (cytosine-5)-methyltransferase 3B isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000328
    UniProtKB/TrEMBL
    A0A8V0YJQ2
    Related
    ENSGALP00010019054.1, ENSGALT00010032264.1
    Conserved Domains (3) summary
    cd05835
    Location:213 → 299
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    cd11728
    Location:401 → 520
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
    cl30459
    Location:544 → 736
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10592207..10605914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046902880.1 → XP_046758836.1  DNA (cytosine-5)-methyltransferase 3B isoform X4

    UniProtKB/TrEMBL
    A0A8V0YS81

  2. XM_046902878.1 → XP_046758834.1  DNA (cytosine-5)-methyltransferase 3B isoform X1

    UniProtKB/TrEMBL
    Q4W5Z3

  3. XM_046902879.1 → XP_046758835.1  DNA (cytosine-5)-methyltransferase 3B isoform X3

    UniProtKB/TrEMBL
    Q4W5Z3

  4. XM_046902881.1 → XP_046758837.1  DNA (cytosine-5)-methyltransferase 3B isoform X5

    UniProtKB/TrEMBL
    A0A8V0YJQ2

  5. XM_040650706.2 → XP_040506640.1  DNA (cytosine-5)-methyltransferase 3B isoform X2

    UniProtKB/TrEMBL
    Q4W5Z3
    Conserved Domains (3) summary
    cd05835
    Location:218 → 304
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    cd11728
    Location:406 → 525
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
    cl30459
    Location:549 → 778
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

  6. XM_040650709.2 → XP_040506643.1  DNA (cytosine-5)-methyltransferase 3B isoform X6

    UniProtKB/TrEMBL
    A0A8V0YJQ2
    Related
    ENSGALP00010019041.1, ENSGALT00010032251.1
    Conserved Domains (3) summary
    cd05835
    Location:194 → 280
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    cd11728
    Location:382 → 501
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)
    cl30459
    Location:525 → 717
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10379581..10393263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046930782.1 → XP_046786738.1  DNA (cytosine-5)-methyltransferase 3B isoform X4

    UniProtKB/TrEMBL
    A0A8V0YS81

  2. XM_046930779.1 → XP_046786735.1  DNA (cytosine-5)-methyltransferase 3B isoform X1

    UniProtKB/TrEMBL
    Q4W5Z3

  3. XM_046930781.1 → XP_046786737.1  DNA (cytosine-5)-methyltransferase 3B isoform X3

    UniProtKB/TrEMBL
    Q4W5Z3

  4. XM_046930783.1 → XP_046786739.1  DNA (cytosine-5)-methyltransferase 3B isoform X5

    UniProtKB/TrEMBL
    A0A8V0YJQ2

  5. XM_046930780.1 → XP_046786736.1  DNA (cytosine-5)-methyltransferase 3B isoform X2

    UniProtKB/TrEMBL
    Q4W5Z3

  6. XM_046930784.1 → XP_046786740.1  DNA (cytosine-5)-methyltransferase 3B isoform X6

    UniProtKB/TrEMBL
    A0A8V0YJQ2
Nucleotide Protein
Heading Accession and Version

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