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HCK HCK proto-oncogene, Src family tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 419280, updated on 13-Apr-2026
Symbol
HCKprovided by CGNC
Full Name
HCK proto-oncogene, Src family tyrosine kinaseprovided by CGNC
Primary source
CGNC:4919
See related
Ensembl:ENSGALG00010015653
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See HCK in Genome Data Viewer
Location:
chromosome: 20
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (10447314..10455096)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (10228969..10242590)

Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene XK related 7 Neighboring gene CCM2 like scaffolding protein Neighboring gene uncharacterized LOC112530123 Neighboring gene transmembrane 9 superfamily member 4 Neighboring gene PLAG1 like zinc finger 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The N-terminal end of the catalytic domain of SRC kinase Hck is a conformational switch implicated in long-range allosteric regulation. Banavali NK, et al. Structure, 2005 Nov. PMID 16271895
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The free energy surface shows that the N-terminal end of HCK acts as a reversible two-state conformational switch coupling the catalytic domain to the regulatory modules.
    Title: The N-terminal end of the catalytic domain of SRC kinase Hck is a conformational switch implicated in long-range allosteric regulation.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosine-protein kinase HCK
Names
hemopoietic cell kinase
XP_004947225.1
XP_004947227.1
XP_040506926.1
XP_040506927.1
XP_040506928.1
XP_040506929.1
XP_040506930.1
XP_040544168.1
XP_040544170.1
XP_040544171.1
XP_040544173.1
XP_040544174.1
XP_046759003.1
XP_046786993.1
XP_046786994.1
XP_046786995.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10447314..10455096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040650994.1 → XP_040506928.1  tyrosine-protein kinase HCK isoform X2

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YUN5
    Conserved Domains (3) summary
    cd05073
    Location:217 → 482
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:107 → 210
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:49 → 104
    SH3; Src Homology 3 domain superfamily

  2. XM_046903047.1 → XP_046759003.1  tyrosine-protein kinase HCK isoform X2

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YUN5

  3. XM_040650993.2 → XP_040506927.1  tyrosine-protein kinase HCK isoform X2

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YUN5
    Conserved Domains (3) summary
    cd05073
    Location:217 → 482
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:107 → 210
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:49 → 104
    SH3; Src Homology 3 domain superfamily

  4. XM_040650995.2 → XP_040506929.1  tyrosine-protein kinase HCK isoform X5

    UniProtKB/TrEMBL
    A0A8V0YLF4
    Conserved Domains (3) summary
    cd05073
    Location:198 → 463
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:88 → 191
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:30 → 85
    SH3; Src Homology 3 domain superfamily

  5. XM_004947168.5 → XP_004947225.1  tyrosine-protein kinase HCK isoform X2

    See identical proteins and their annotated locations for XP_004947225.1

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YUN5
    Related
    ENSGALP00010021781.1, ENSGALT00010037695.1
    Conserved Domains (3) summary
    cd05073
    Location:217 → 482
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:107 → 210
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:49 → 104
    SH3; Src Homology 3 domain superfamily

  6. XM_040650992.2 → XP_040506926.1  tyrosine-protein kinase HCK isoform X1

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YT43
    Related
    ENSGALP00010021777.1, ENSGALT00010037688.1
    Conserved Domains (3) summary
    cd05073
    Location:252 → 517
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:142 → 245
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:84 → 139
    SH3; Src Homology 3 domain superfamily

  7. XM_040650996.1 → XP_040506930.1  tyrosine-protein kinase HCK isoform X3

    UniProtKB/TrEMBL
    A0A8V0YLF4
    Conserved Domains (3) summary
    cl15255
    Location:142 → 245
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:84 → 139
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:252 → 456
    PKc_like; Protein Kinases, catalytic domain

  8. XM_004947170.4 → XP_004947227.1  tyrosine-protein kinase HCK isoform X4

    UniProtKB/TrEMBL
    A0A8V0YLF4
    Conserved Domains (3) summary
    cd05073
    Location:159 → 424
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:49 → 152
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:1 → 46
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_005841297.1 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10228969..10242590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040688240.1 → XP_040544174.1  tyrosine-protein kinase HCK isoform X2

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YUN5
    Conserved Domains (3) summary
    cd05073
    Location:217 → 482
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:107 → 210
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:49 → 104
    SH3; Src Homology 3 domain superfamily

  2. XM_046931037.1 → XP_046786993.1  tyrosine-protein kinase HCK isoform X2

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YUN5

  3. XM_040688236.2 → XP_040544170.1  tyrosine-protein kinase HCK isoform X1

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YT43
    Conserved Domains (3) summary
    cd05073
    Location:252 → 517
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:142 → 245
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:84 → 139
    SH3; Src Homology 3 domain superfamily

  4. XM_046931038.1 → XP_046786994.1  tyrosine-protein kinase HCK isoform X3

    UniProtKB/TrEMBL
    A0A8V0YLF4

  5. XM_046931039.1 → XP_046786995.1  tyrosine-protein kinase HCK isoform X4

    UniProtKB/TrEMBL
    A0A8V0YLF4

  6. XM_040688239.2 → XP_040544173.1  tyrosine-protein kinase HCK isoform X2

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YUN5
    Conserved Domains (3) summary
    cd05073
    Location:217 → 482
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:107 → 210
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:49 → 104
    SH3; Src Homology 3 domain superfamily

  7. XM_040688234.2 → XP_040544168.1  tyrosine-protein kinase HCK isoform X1

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YT43
    Conserved Domains (3) summary
    cd05073
    Location:252 → 517
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:142 → 245
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:84 → 139
    SH3; Src Homology 3 domain superfamily

  8. XM_040688237.2 → XP_040544171.1  tyrosine-protein kinase HCK isoform X2

    UniProtKB/TrEMBL
    A0A8V0YLF4, A0A8V0YUN5
    Conserved Domains (3) summary
    cd05073
    Location:217 → 482
    PTKc_Hck; Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase
    cl15255
    Location:107 → 210
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:49 → 104
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_006936815.1 RNA Sequence

Nucleotide Protein
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