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VWF von Willebrand factor [ Gallus gallus (chicken) ]

Gene ID: 419031, updated on 3-Dec-2024

Summary

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Symbol
VWFprovided by CGNC
Full Name
von Willebrand factorprovided by CGNC
Primary source
CGNC:12976
See related
Ensembl:ENSGALG00010024534
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See VWF in Genome Data Viewer
Location:
chromosome: 1
Exon count:
52
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (74643818..74782490, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (74972701..75111476, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene neurotrophin 3 Neighboring gene anoctamin 2 Neighboring gene uncharacterized LOC124417639 Neighboring gene NOBOX oogenesis homeobox Neighboring gene CD9 molecule Neighboring gene uncharacterized LOC107055509 Neighboring gene Rho guanine nucleotide exchange factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. Dang LT, et al. J Biol Chem, 2011 Jul 22. PMID 21592973, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
von Willebrand factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318464.2 → NP_001305393.2  von Willebrand factor precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    A0A8V0ZYI4, F5XVB5
    Related
    ENSGALP00010036764.1, ENSGALT00010060004.1
    Conserved Domains (6) summary
    smart00214
    Location:2247 → 2308
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:374 → 537
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:1674 → 1828
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:1059 → 1126
    C8; This domain contains 8 conserved cysteine residues
    cd01450
    Location:1484 → 1635
    vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl21545
    Location:2714 → 2794
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    74643818..74782490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040700457.2 → XP_040556391.1  von Willebrand factor isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZYH9
    Related
    ENSGALP00010036758.1, ENSGALT00010059997.1
    Conserved Domains (7) summary
    smart00214
    Location:2148 → 2209
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:275 → 438
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:1575 → 1729
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:960 → 1027
    C8; This domain contains 8 conserved cysteine residues
    cd01450
    Location:1385 → 1536
    vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl02516
    Location:3 → 76
    VWD; von Willebrand factor type D domain
    cl21545
    Location:2615 → 2695
    GHB_like; Glycoprotein hormone beta chain homologues

  2. XM_046942139.1 → XP_046798095.1  von Willebrand factor isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZYH9

  3. XM_040700449.2 → XP_040556383.1  von Willebrand factor isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZYI4, F5XVB5
    Conserved Domains (6) summary
    smart00214
    Location:2247 → 2308
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:374 → 537
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:1674 → 1828
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:1059 → 1126
    C8; This domain contains 8 conserved cysteine residues
    cd01450
    Location:1484 → 1635
    vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl21545
    Location:2714 → 2794
    GHB_like; Glycoprotein hormone beta chain homologues

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    74972701..75111476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046908366.1 → XP_046764322.1  von Willebrand factor isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZYH9

  2. XM_046908365.1 → XP_046764321.1  von Willebrand factor isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZYH9

  3. XM_046908364.1 → XP_046764320.1  von Willebrand factor isoform X1

    UniProtKB/TrEMBL
    F5XVB5
Nucleotide Protein Strain
Heading Accession and Version

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