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ART3 ADP-ribosyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 419, updated on 21-Dec-2017
Official Symbol
ART3provided by HGNC
Official Full Name
ADP-ribosyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:725
See related
Ensembl:ENSG00000156219 MIM:603086; Vega:OTTHUMG00000130110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTC3
Summary
This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Biased expression in testis (RPKM 18.7) and heart (RPKM 6.2) See more
Orthologs
Location:
4q21.1; 4p15.1-p14
Exon count:
15
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (76011180..76112802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76932333..77033955)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene uncharacterized LOC101928809 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene ribosomal protein L36 pseudogene 8 Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene nucleoporin 54 Neighboring gene scavenger receptor class B member 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ26404

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
C-terminal protein lipidation TAS
Traceable Author Statement
more info
 
protein ADP-ribosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
ecto-ADP-ribosyltransferase 3
Names
ADP-ribosyltransferase C2 and C3 toxin-like 3
NAD(P)(+)--arginine ADP-ribosyltransferase 3
mono(ADP-ribosyl)transferase 3
mono-ADP-ribosyltransferase
NP_001123488.1
NP_001123489.1
NP_001170.2
XP_005263054.1
XP_005263056.1
XP_005263060.1
XP_005263061.1
XP_006714283.1
XP_011530273.1
XP_016863695.1
XP_016863696.1
XP_016863697.1
XP_016863698.1
XP_016863699.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130016.2NP_001123488.1  ecto-ADP-ribosyltransferase 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001123488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC112719, AK225860, BC008397, BC017913
    Consensus CDS
    CCDS47079.1
    UniProtKB/Swiss-Prot
    Q13508
    Related
    ENSP00000348064.4, OTTHUMP00000160603, ENST00000355810.8, OTTHUMT00000252416
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  2. NM_001130017.2NP_001123489.1  ecto-ADP-ribosyltransferase 3 isoform c precursor

    See identical proteins and their annotated locations for NP_001123489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment and differs in the 5' UTR compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC112719, AK225860, BC017913, DB451386
    Consensus CDS
    CCDS47080.1
    UniProtKB/Swiss-Prot
    Q13508
    Related
    ENSP00000343843.5, OTTHUMP00000219067, ENST00000341029.9, OTTHUMT00000362484
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  3. NM_001179.5NP_001170.2  ecto-ADP-ribosyltransferase 3 isoform b precursor

    See identical proteins and their annotated locations for NP_001170.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC112719, AK225860, BC017913
    Consensus CDS
    CCDS3575.1
    UniProtKB/Swiss-Prot
    Q13508
    Related
    ENSP00000304313.5, OTTHUMP00000160604, ENST00000349321.7, OTTHUMT00000252417
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

    Range
    76011180..76112802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008208.1XP_016863697.1  ecto-ADP-ribosyltransferase 3 isoform X3

  2. XM_017008210.1XP_016863699.1  ecto-ADP-ribosyltransferase 3 isoform X11

  3. XM_005262997.1XP_005263054.1  ecto-ADP-ribosyltransferase 3 isoform X4

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  4. XM_005262999.1XP_005263056.1  ecto-ADP-ribosyltransferase 3 isoform X6

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  5. XM_005263004.1XP_005263061.1  ecto-ADP-ribosyltransferase 3 isoform X10

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  6. XM_017008209.1XP_016863698.1  ecto-ADP-ribosyltransferase 3 isoform X5

  7. XM_011531971.1XP_011530273.1  ecto-ADP-ribosyltransferase 3 isoform X7

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  8. XM_006714220.1XP_006714283.1  ecto-ADP-ribosyltransferase 3 isoform X8

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  9. XM_005263003.1XP_005263060.1  ecto-ADP-ribosyltransferase 3 isoform X9

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  10. XM_017008206.1XP_016863695.1  ecto-ADP-ribosyltransferase 3 isoform X1

  11. XM_017008207.1XP_016863696.1  ecto-ADP-ribosyltransferase 3 isoform X2

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    76908897..77010440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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