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ART3 ADP-ribosyltransferase 3 (inactive) [ Homo sapiens (human) ]

Gene ID: 419, updated on 9-Dec-2024

Summary

Official Symbol
ART3provided by HGNC
Official Full Name
ADP-ribosyltransferase 3 (inactive)provided by HGNC
Primary source
HGNC:HGNC:725
See related
Ensembl:ENSG00000156219 MIM:603086; AllianceGenome:HGNC:725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTC3
Summary
This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Biased expression in testis (RPKM 18.7) and heart (RPKM 6.2) See more
Orthologs
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Genomic context

See ART3 in Genome Data Viewer
Location:
4q21.1; 4p15.1-p14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (76011190..76112786)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (79351693..79453452)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76932343..77033939)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene SDAD1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76932273-76932917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:76938237-76938736 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene ribosomal protein L36 pseudogene 8 Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene NANOG hESC enhancer GRCh37_chr4:77016693-77017194 Neighboring gene nucleoporin 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21626 Neighboring gene uncharacterized LOC124900718 Neighboring gene NANOG hESC enhancer GRCh37_chr4:77075501-77076330 Neighboring gene scavenger receptor class B member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ26404

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ecto-ADP-ribosyltransferase 3
Names
ADP-ribosyltransferase C2 and C3 toxin-like 3
NAD(P)(+)--arginine ADP-ribosyltransferase 3
mono(ADP-ribosyl)transferase 3
mono-ADP-ribosyltransferase
NP_001123488.1
NP_001123489.1
NP_001170.2
NP_001364102.1
NP_001364103.1
NP_001364104.1
NP_001364105.1
NP_001364106.1
NP_001364107.1
NP_001364108.1
NP_001364109.1
NP_001364110.1
NP_001364111.1
NP_001364112.1
NP_001364113.1
NP_001364114.1
XP_016863695.1
XP_024309818.1
XP_024309819.1
XP_024309820.1
XP_024309821.1
XP_024309822.1
XP_024309824.1
XP_024309826.1
XP_024309827.1
XP_024309829.1
XP_024309830.1
XP_024309831.1
XP_047271651.1
XP_047271652.1
XP_047271653.1
XP_047271654.1
XP_047271655.1
XP_047271656.1
XP_054206006.1
XP_054206007.1
XP_054206008.1
XP_054206009.1
XP_054206010.1
XP_054206011.1
XP_054206012.1
XP_054206013.1
XP_054206014.1
XP_054206015.1
XP_054206016.1
XP_054206017.1
XP_054206018.1
XP_054206019.1
XP_054206020.1
XP_054206021.1
XP_054206022.1
XP_054206023.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130016.3NP_001123488.1  ecto-ADP-ribosyltransferase 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001123488.1

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS47079.1
    UniProtKB/Swiss-Prot
    Q13508, Q53XW3, Q6FHT7, Q8WVJ7, Q93069, Q96HL1
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Related
    ENSP00000348064.4, ENST00000355810.9
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  2. NM_001130017.3NP_001123489.1  ecto-ADP-ribosyltransferase 3 isoform c precursor

    See identical proteins and their annotated locations for NP_001123489.1

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS47080.1
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Related
    ENSP00000343843.5, ENST00000341029.9
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  3. NM_001179.6NP_001170.2  ecto-ADP-ribosyltransferase 3 isoform b precursor

    See identical proteins and their annotated locations for NP_001170.2

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS3575.1
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Related
    ENSP00000304313.5, ENST00000349321.7
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  4. NM_001377173.1NP_001364102.1  ecto-ADP-ribosyltransferase 3 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS93546.1
    UniProtKB/TrEMBL
    H0Y8V6
    Related
    ENSP00000422249.2, ENST00000511188.2
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  5. NM_001377174.1NP_001364103.1  ecto-ADP-ribosyltransferase 3 isoform l precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  6. NM_001377175.1NP_001364104.1  ecto-ADP-ribosyltransferase 3 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS47080.1
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  7. NM_001377176.1NP_001364105.1  ecto-ADP-ribosyltransferase 3 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  8. NM_001377177.1NP_001364106.1  ecto-ADP-ribosyltransferase 3 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  9. NM_001377178.1NP_001364107.1  ecto-ADP-ribosyltransferase 3 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  10. NM_001377179.1NP_001364108.1  ecto-ADP-ribosyltransferase 3 isoform g precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  11. NM_001377180.1NP_001364109.1  ecto-ADP-ribosyltransferase 3 isoform h precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  12. NM_001377181.1NP_001364110.1  ecto-ADP-ribosyltransferase 3 isoform i precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  13. NM_001377182.1NP_001364111.1  ecto-ADP-ribosyltransferase 3 isoform i precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  14. NM_001377183.1NP_001364112.1  ecto-ADP-ribosyltransferase 3 isoform j precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  15. NM_001377184.1NP_001364113.1  ecto-ADP-ribosyltransferase 3 isoform j precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  16. NM_001377185.1NP_001364114.1  ecto-ADP-ribosyltransferase 3 isoform k precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    76011190..76112786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415697.1XP_047271653.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8V8TQ78
  2. XM_047415700.1XP_047271656.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
  3. XM_047415695.1XP_047271651.1  ecto-ADP-ribosyltransferase 3 isoform X4

    UniProtKB/TrEMBL
    A0A8V8TQ78
  4. XM_047415696.1XP_047271652.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8V8TQ78
  5. XM_047415699.1XP_047271655.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
  6. XM_047415698.1XP_047271654.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8V8TQ78
  7. XM_024454063.2XP_024309831.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  8. XM_024454053.2XP_024309821.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  9. XM_024454052.2XP_024309820.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  10. XM_017008206.3XP_016863695.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  11. XM_024454051.2XP_024309819.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  12. XM_024454062.2XP_024309830.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
    Related
    ENSP00000514989.1, ENST00000700440.1
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  13. XM_024454056.2XP_024309824.1  ecto-ADP-ribosyltransferase 3 isoform X3

    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  14. XM_024454058.2XP_024309826.1  ecto-ADP-ribosyltransferase 3 isoform X5

    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  15. XM_024454059.2XP_024309827.1  ecto-ADP-ribosyltransferase 3 isoform X6

    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  16. XM_024454061.2XP_024309829.1  ecto-ADP-ribosyltransferase 3 isoform X8

    UniProtKB/TrEMBL
    A0A8V8TQ78
    Related
    ENSP00000514990.1, ENST00000700441.1
    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  17. XM_024454050.2XP_024309818.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase
  18. XM_024454054.2XP_024309822.1  ecto-ADP-ribosyltransferase 3 isoform X2

    Conserved Domains (1) summary
    pfam01129
    Location:29252
    ART; NAD:arginine ADP-ribosyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    79351693..79453452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350042.1XP_054206017.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8V8TQ78
  2. XM_054350047.1XP_054206022.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
  3. XM_054350038.1XP_054206013.1  ecto-ADP-ribosyltransferase 3 isoform X4

    UniProtKB/TrEMBL
    A0A8V8TQ78
  4. XM_054350041.1XP_054206016.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8V8TQ78
  5. XM_054350046.1XP_054206021.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
  6. XM_054350043.1XP_054206018.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8V8TQ78
  7. XM_054350048.1XP_054206023.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
  8. XM_054350035.1XP_054206010.1  ecto-ADP-ribosyltransferase 3 isoform X1

  9. XM_054350032.1XP_054206007.1  ecto-ADP-ribosyltransferase 3 isoform X1

  10. XM_054350033.1XP_054206008.1  ecto-ADP-ribosyltransferase 3 isoform X1

  11. XM_054350031.1XP_054206006.1  ecto-ADP-ribosyltransferase 3 isoform X1

  12. XM_054350045.1XP_054206020.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
  13. XM_054350037.1XP_054206012.1  ecto-ADP-ribosyltransferase 3 isoform X3

    UniProtKB/TrEMBL
    A0A8V8TQ78
  14. XM_054350039.1XP_054206014.1  ecto-ADP-ribosyltransferase 3 isoform X5

    UniProtKB/TrEMBL
    A0A8V8TQ78
  15. XM_054350040.1XP_054206015.1  ecto-ADP-ribosyltransferase 3 isoform X6

    UniProtKB/TrEMBL
    A0A8V8TQ78
  16. XM_054350044.1XP_054206019.1  ecto-ADP-ribosyltransferase 3 isoform X8

    UniProtKB/TrEMBL
    A0A8V8TQ78
  17. XM_054350034.1XP_054206009.1  ecto-ADP-ribosyltransferase 3 isoform X1

  18. XM_054350036.1XP_054206011.1  ecto-ADP-ribosyltransferase 3 isoform X2