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Cyfip Cytoplasmic FMR1 interacting protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41861, updated on 3-Jun-2026
Official Symbol
Cyfipprovided by FlyBase
Official Full Name
Cytoplasmic FMR1 interacting proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038320
Locus tag
Dmel_CG4931
See related
AllianceGenome:FB:FBgn0038320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4931; cyfip; CYFIP; CYFIP1; CYFIP1/2; dCyfip; dCYFIP; dCYFIP1; Dmel\CG4931; dSra; DSra-1; PIR121; PIR121/Sra-1; Sra; sra-1; Sra-1; Sra-1/CYFIP; sra1; Sra1; Sra1/PIR121
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity. Involved in several processes, including cell adhesion mediated by integrin; centripetally migrating follicle cell migration; and positive regulation of filopodium assembly. Located in apical part of cell and cytoplasm. Part of SCAR complex. Is expressed in several structures, including adult head; embryonic/larval gut; embryonic/larval neuromuscular junction; ganglia; and tract. Used to study chromosome 15q11.2 deletion syndrome. Human ortholog(s) of this gene implicated in autism spectrum disorder; developmental and epileptic encephalopathy 65; and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1) and CYFIP2 (cytoplasmic FMR1 interacting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Cyfip in Genome Data Viewer
Location:
88F1-88F1; 3-57 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15333266..15338365)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11158988..11164087)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene easter Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene FK506-binding protein 39kD Neighboring gene N-acetylglucosamine kinase Neighboring gene Seryl-tRNA synthetase, mitochondrial Neighboring gene Surfeit 4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization. Mariano V, et al. Biol Psychiatry, 2024 Jan 15. PMID 37704042
  2. Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly. Zhao L, et al. PLoS Genet, 2013 Apr. PMID 23593037, Free PMC Article
  3. Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology. Banka S, et al. Brain, 2022 Dec 19. PMID 35139179, Free PMC Article
  4. Domain-Specific Cognitive Impairments in Humans and Flies With Reduced CYFIP1 Dosage. Woo YJ, et al. Biol Psychiatry, 2019 Aug 15. PMID 31202490, Free PMC Article
  5. Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. Reeve SP, et al. J Neurosci, 2008 Mar 19. PMID 18354025, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study examined aspects of sensory and cognitive function in flies harboring a mutation in Cyfip, the homologue of one of the genes within the deletion.
    Title: Domain-Specific Cognitive Impairments in Humans and Flies With Reduced CYFIP1 Dosage.
  2. These results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction.
    Title: New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes.
  3. We propose that Cyfip regulates synapse development and endocytosis by inhibiting actin assembly.
    Title: Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly.
  4. Mutations in WAVE/SCAR and in ARP2/3 complex subunits but not in WASP, another major regulator of Actin nucleation, phenocopy CYFIP defects. Thus, the CYFIP-SCAR-ARP2/3 pathway orchestrates specific tissue remodeling processes
    Title: CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis.
  5. Sra-1 function is mediated through kette. These stabilize each other and directly control the regulation of the cytoskeleton.
    Title: Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila.
  6. CYFIP specifically expressed in the nervous system; mutations affect axons and synapses, much like mutations in dFMR1 and Rho GTPase dRac1; CYFIP acts as a dRac1 effector that antagonizes FMR1 function
    Title: CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centripetally migrating follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCAR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCAR complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Preferred Names
cytoplasmic FMR1 interacting protein
Names
CG4931-PA
Cyfip-PA
specifically Rac1-associated protein 1
specifically, Rac-1 associated protein 1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15333266..15338365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142190.3 → NP_650447.1  cytoplasmic FMR1 interacting protein

    See identical proteins and their annotated locations for NP_650447.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NP16, Q8MR06, Q9VF87
    UniProtKB/TrEMBL
    U3PXB4
    Related
    FBpp0082541
    Conserved Domains (2) summary
    pfam05994
    Location:386 → 1244
    FragX_IP; Cytoplasmic Fragile-X interacting family
    pfam07159
    Location:89 → 267
    DUF1394; Protein of unknown function (DUF1394)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VF87.1 Q9VF87

Gene LinkOut

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