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KLHL15 kelch like protein 15 [ Gallus gallus (chicken) ]

Gene ID: 418598, updated on 19-Jun-2026
Official Symbol
KLHL15provided by CGNC
Official Full Name
kelch like protein 15provided by CGNC
Primary source
CGNC:12229
See related
Ensembl:ENSGALG00010003101
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See KLHL15 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (118347837..118376901)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (118376540..118405611)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein X Neighboring gene uncharacterized LOC107049214 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma Neighboring gene apolipoprotein O Neighboring gene spermidine/spermine N1-acetyltransferase 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear protein quality control by the ubiquitin-proteasome system IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
kelch-like protein 15
Names
kelch like family member 15
kelch-like 15

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030802.2 → NP_001025973.2  kelch-like protein 15 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in 5' UTR and the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AJ720342, AJ738287, HAEK01005891, JAENSK010000021
    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    F1NNV8
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 487
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:321 → 365
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  2. NM_001143670.2 → NP_001137142.1  kelch-like protein 15 isoform 1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    JAENSK010000021
    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2
    Related
    ENSGALP00010004338.1, ENSGALT00010007214.1
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 590
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    118347837..118376901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015302426.4 → XP_015157912.1  kelch-like protein 15 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    F1NNV8
    Related
    ENSGALP00010004335.1, ENSGALT00010007210.1
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 487
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:321 → 365
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  2. XM_046940558.1 → XP_046796514.1  kelch-like protein 15 isoform X3

  3. XM_046940563.1 → XP_046796519.1  kelch-like protein 15 isoform X4

  4. XM_015302410.4 → XP_015157896.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 590
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  5. XM_015302385.4 → XP_015157871.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 590
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  6. XM_015302389.4 → XP_015157875.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 590
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  7. XM_040698678.2 → XP_040554612.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 590
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  8. XM_046940548.1 → XP_046796504.1  kelch-like protein 15 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    F1NNV8

  9. XM_015302402.4 → XP_015157888.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 590
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  10. XM_015302416.4 → XP_015157902.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 590
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  11. XM_015302394.4 → XP_015157880.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 590
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  12. XM_046940564.1 → XP_046796520.1  kelch-like protein 15 isoform X4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    118376540..118405611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046907946.1 → XP_046763902.1  kelch-like protein 15 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    F1NNV8

  2. XM_046907948.1 → XP_046763904.1  kelch-like protein 15 isoform X3

  3. XM_046907949.1 → XP_046763905.1  kelch-like protein 15 isoform X4

  4. XM_046907945.1 → XP_046763901.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2

  5. XM_046907939.1 → XP_046763895.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2

  6. XM_046907943.1 → XP_046763899.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2

  7. XM_046907944.1 → XP_046763900.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2

  8. XM_046907947.1 → XP_046763903.1  kelch-like protein 15 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    F1NNV8

  9. XM_046907941.1 → XP_046763897.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2

  10. XM_046907942.1 → XP_046763898.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2

  11. XM_046907940.1 → XP_046763896.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZJU2
    UniProtKB/TrEMBL
    A0A1D5PHT3, A0A1D5PIX2

  12. XM_046907950.1 → XP_046763906.1  kelch-like protein 15 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZJU2.1 GenPept UniProtKB/Swiss-Prot:Q5ZJU2

Gene LinkOut

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Research Materials