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TMPRSS2 transmembrane protease, serine 2 [ Gallus gallus (chicken) ]

Gene ID: 418528, updated on 3-Dec-2024
Symbol
TMPRSS2provided by CGNC
Full Name
transmembrane protease, serine 2provided by CGNC
Primary source
CGNC:12069
See related
Ensembl:ENSGALG00010013833
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Location:
chromosome: 1
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (109023600..109044043, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (109107185..109127609, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 3 member B Neighboring gene MX dynamin like GTPase 1 Neighboring gene uncharacterized LOC107056158 Neighboring gene receptor interacting serine/threonine kinase 4 Neighboring gene PR/SET domain 15

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
transmembrane protease serine 2
Names
transmembrane serine protease 2
XP_015156666.1
XP_040508208.1
XP_040515615.1
XP_040515616.1
XP_040515617.1
XP_046761758.1
XP_046761764.1
XP_046765666.1
XP_046765667.1
XP_416737.4

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    109023600..109044043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_416737.8 → XP_416737.4  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88
    Related
    ENSGALP00010019622.1, ENSGALT00010033210.1
    Conserved Domains (3) summary
    cd00112
    Location:105 → 140
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:250 → 481
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:145 → 241
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. XM_015301180.4 → XP_015156666.1  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88
    Related
    ENSGALP00010019619.1, ENSGALT00010033205.1
    Conserved Domains (3) summary
    cd00112
    Location:105 → 140
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:250 → 481
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:145 → 241
    SRCR_2; Scavenger receptor cysteine-rich domain

  3. XM_046905802.1 → XP_046761758.1  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88

  4. XM_040652274.2 → XP_040508208.1  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88
    Conserved Domains (3) summary
    cd00112
    Location:105 → 140
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:250 → 481
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:145 → 241
    SRCR_2; Scavenger receptor cysteine-rich domain

  5. XM_046905808.1 → XP_046761764.1  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    109107185..109127609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040659681.2 → XP_040515615.1  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88
    Conserved Domains (3) summary
    cd00112
    Location:105 → 140
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:250 → 481
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:145 → 241
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. XM_040659682.2 → XP_040515616.1  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88
    Conserved Domains (3) summary
    cd00112
    Location:105 → 140
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:250 → 481
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:145 → 241
    SRCR_2; Scavenger receptor cysteine-rich domain

  3. XM_046909710.1 → XP_046765666.1  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88

  4. XM_040659683.2 → XP_040515617.1  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88
    Conserved Domains (3) summary
    cd00112
    Location:105 → 140
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:250 → 481
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:145 → 241
    SRCR_2; Scavenger receptor cysteine-rich domain

  5. XM_046909711.1 → XP_046765667.1  transmembrane protease serine 2

    UniProtKB/TrEMBL
    A0A8V0YFK4, F1NY88
Nucleotide Protein
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