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Tm1 Tropomyosin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41852, updated on 8-Apr-2026
Official Symbol
Tm1provided by FlyBase
Official Full Name
Tropomyosin 1provided by FlyBase
Primary source
FLYBASE:FBgn0003721
Locus tag
Dmel_CG4898
See related
AllianceGenome:FB:FBgn0003721
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1305/10; 2299; BcDNA:GH09289; BcDNA:LD37158; BcDNA:SD21996; CG4898; chr3R:11122272..11122408; cTm; cTM; cTmII; Dm Tm1; Dm TmH33; Dm TmH34; Dmel\CG4898; DmTm1; l(3)02299; l(3)S130510; l(3)s2958; mTmII; PmI; region 3; Tm; TM; tm1; TM1; TmH; TmH-33; TmH-34; TmH33; TmH34; tmII; TmII; TMII; Tmr33; Tmr34; TnH; TnH-33; TnH-34; tropomyosin
Summary
Enables actin filament binding activity; kinesin binding activity; and protein kinase binding activity. Involved in several processes, including dendrite morphogenesis; pole plasm oskar mRNA localization; and stress fiber assembly. Located in P granule; investment cone; and sarcomere. Colocalizes with cortical actin cytoskeleton and stress fiber. Is expressed in several structures, including epithelium; ganglia; germline cell; gut section; and somatic cell of ovariole. Human ortholog(s) of this gene implicated in blood platelet disease; intrinsic cardiomyopathy (multiple); and muscle tissue disease (multiple). Orthologous to human TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM4 (tropomyosin 4). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Tm1 in Genome Data Viewer
Location:
88E11-88E13; 3-56 cM
Exon count:
22
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15278220..15308779)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11107093..11134501)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46081 Neighboring gene uncharacterized protein Neighboring gene lethal (3) neo43 Neighboring gene MORF-related gene 15 Neighboring gene uncharacterized protein Neighboring gene Tropomyosin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Polymorphism in a Drosophila indirect flight muscle-specific tropomyosin isozyme does not affect flight ability. Cripps RM, et al. Biochem Genet, 1992 Apr. PMID 1590747
  2. Dynamic structural order of a low-complexity domain facilitates assembly of intermediate filaments. Sysoev VO, et al. Proc Natl Acad Sci U S A, 2020 Sep 22. PMID 32907935, Free PMC Article
  3. An Atypical Tropomyosin in Drosophila with Intermediate Filament-like Properties. Cho A, et al. Cell Rep, 2016 Jul 26. PMID 27396338, Free PMC Article
  4. Developmental regulation of the Drosophila tropomyosin II gene in different muscles is controlled by muscle-type-specific intron enhancer elements and distal and proximal promoter control elements. Meredith J, et al. Dev Biol, 1993 Oct. PMID 8405674
  5. Transcriptional and post-transcriptional regulation of maternal and zygotic cytoskeletal tropomyosin mRNA during Drosophila development correlates with specific morphogenic events. Hales KH, et al. Dev Biol, 1994 Oct. PMID 7958428

See all (258) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tm1C-Khc interaction is specific for the osk localization pathway.
    Title: A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization.
  2. The authors demonstrate that kinesin-1 recruitment requires the DmTropomyosin1-I/C isoform, an atypical RNA-binding tropomyosin that binds directly to dimerizing oskar 3'UTRs.
    Title: An RNA-binding atypical tropomyosin recruits kinesin-1 dynamically to oskar mRNPs.
  3. analysis of arrhythmia caused by a Drosophila tropomyosin mutation using optical coherence tomography
    Title: Arrhythmia caused by a Drosophila tropomyosin mutation is revealed using a novel optical coherence tomography instrument.
  4. We report here that tropomyosins are post-translationally modified by several phosphorylations in their C-termini in mature flies, but not in recently emerged flies that are incapable of flight.
    Title: The structural role of high molecular weight tropomyosins in dipteran indirect flight muscle and the effect of phosphorylation.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding TAS
Traceable Author Statement
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle contraction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in oogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in pole plasm assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm oskar mRNA localization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hyperoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cortical actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in investment cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcomere IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with stress fiber IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
tropomyosin 1
Names
CG4898-PA
CG4898-PC
CG4898-PE
CG4898-PF
CG4898-PG
CG4898-PH
CG4898-PI
CG4898-PJ
CG4898-PK
CG4898-PL
CG4898-PM
CG4898-PN
CG4898-PO
CG4898-PP
CG4898-PQ
CG4898-PR
CG4898-PS
CG4898-PT
Tm1-PA
Tm1-PC
Tm1-PE
Tm1-PF
Tm1-PG
Tm1-PH
Tm1-PI
Tm1-PJ
Tm1-PK
Tm1-PL
Tm1-PM
Tm1-PN
Tm1-PO
Tm1-PP
Tm1-PQ
Tm1-PR
Tm1-PS
Tm1-PT
Tropomyosin-1
Tropomyosin1
cytoplasmic tropomyosin
cytoskeletal tropomyosin
tropomyosin
tropomyosin I
tropomyosin II
tropomyosinII
tropomysin II
troponin H
troponin-H
troponin-H isoform 34

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15278220..15308779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382175.1 → NP_001369014.1  tropomyosin 1, isoform T

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EG56
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 275
    Tropomyosin

  2. NM_169635.3 → NP_732003.1  tropomyosin 1, isoform G

    See identical proteins and their annotated locations for NP_732003.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06754
    Related
    FBpp0088903
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  3. NM_206495.2 → NP_996217.1  tropomyosin 1, isoform K

    See identical proteins and their annotated locations for NP_996217.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49455, P49456, Q24425, Q24426, Q7KSH9, Q7KSI0
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 281
    Tropomyosin; Tropomyosin

  4. NM_169637.4 → NP_732005.2  tropomyosin 1, isoform F

    See identical proteins and their annotated locations for NP_732005.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UUP7, Q058U3
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 281
    Tropomyosin; Tropomyosin

  5. NM_001260190.1 → NP_001247119.1  tropomyosin 1, isoform P

    See identical proteins and their annotated locations for NP_001247119.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6Y8
    Conserved Domains (2) summary
    pfam08537
    Location:2 → 106
    NBP1; Fungal Nap binding protein NBP1
    pfam12718
    Location:7 → 127
    Tropomyosin_1; Tropomyosin like

  6. NM_169633.5 → NP_732001.3  tropomyosin 1, isoform O

    See identical proteins and their annotated locations for NP_732001.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06754
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  7. NM_169638.4 → NP_732006.2  tropomyosin 1, isoform E

    See identical proteins and their annotated locations for NP_732006.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGY1, Q8INE5
    Related
    FBpp0088904
    Conserved Domains (1) summary
    pfam12718
    Location:517 → 648
    Tropomyosin_1; Tropomyosin like

  8. NM_001275662.1 → NP_001262591.1  tropomyosin 1, isoform S

    See identical proteins and their annotated locations for NP_001262591.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG06
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  9. NM_001170148.2 → NP_001163619.1  tropomyosin 1, isoform N

    See identical proteins and their annotated locations for NP_001163619.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN28
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  10. NM_169634.3 → NP_732002.1  tropomyosin 1, isoform M

    See identical proteins and their annotated locations for NP_732002.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06754
    Related
    FBpp0291171
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  11. NM_169636.3 → NP_732004.1  tropomyosin 1, isoform J

    See identical proteins and their annotated locations for NP_732004.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06754
    Related
    FBpp0088906
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  12. NM_206494.3 → NP_996216.1  tropomyosin 1, isoform L

    See identical proteins and their annotated locations for NP_996216.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06754
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  13. NM_169639.3 → NP_732007.2  tropomyosin 1, isoform H

    See identical proteins and their annotated locations for NP_732007.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IG84, Q8INE4
    Related
    FBpp0088902
    Conserved Domains (1) summary
    cl19758
    Location:506 → 612
    FH2; Formin Homology 2 Domain

  14. NM_169640.4 → NP_732008.1  tropomyosin 1, isoform C

    See identical proteins and their annotated locations for NP_732008.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TA3
    Related
    FBpp0088901
    Conserved Domains (1) summary
    cl19758
    Location:269 → 375
    FH2; Formin Homology 2 Domain

  15. NM_169641.4 → NP_732009.2  tropomyosin 1, isoform I

    See identical proteins and their annotated locations for NP_732009.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TA3
    Related
    FBpp0088900
    Conserved Domains (1) summary
    cl19758
    Location:269 → 375
    FH2; Formin Homology 2 Domain

  16. NM_079636.4 → NP_524360.2  tropomyosin 1, isoform A

    See identical proteins and their annotated locations for NP_524360.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06754
    Related
    FBpp0088899
    Conserved Domains (1) summary
    pfam00261
    Location:16 → 250
    Tropomyosin

  17. NM_001275661.1 → NP_001262590.1  tropomyosin 1, isoform R

    See identical proteins and their annotated locations for NP_001262590.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG68
    Conserved Domains (1) summary
    pfam00261
    Location:16 → 243
    Tropomyosin

  18. NM_001260191.1 → NP_001247120.1  tropomyosin 1, isoform Q

    See identical proteins and their annotated locations for NP_001247120.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K661, C1C3D3
    Conserved Domains (1) summary
    pfam00261
    Location:16 → 243
    Tropomyosin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K661 A0A0B4K661
A0A0B4K6Y8 A0A0B4K6Y8
A0A0B4KG06 A0A0B4KG06
A0A0B4KG68 A0A0B4KG68
A0A6H2EG56 A0A6H2EG56
P06754.2 P06754
P49455.2 P49455
Q6LEH1 Q6LEH1
Q6NN28 Q6NN28
Q8IG84 Q8IG84
Q8IGY1 Q8IGY1
Q95TA3 Q95TA3

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