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MRG15 MORF-related gene 15 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41850, updated on 8-Apr-2026
Official Symbol
MRG15provided by FlyBase
Official Full Name
MORF-related gene 15provided by FlyBase
Primary source
FLYBASE:FBgn0027378
Locus tag
Dmel_CG6363
See related
AllianceGenome:FB:FBgn0027378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6363; Dmel\CG6363; DmMRG15; dMrg15; dMRG15; Dmrg15; l(3)j6A3; MRG-15; mrg15; Mrg15
Summary
Enables chromatin binding activity; enzyme regulator activity; and methylated histone binding activity. Involved in several processes, including chromatin remodeling; chromosome separation; and positive regulation of gene expression. Located in nucleus. Part of NuA4 histone acetyltransferase complex and histone methyltransferase complex. Is expressed in several structures, including adult head; central brain primordium; ganglia; larval nervous system; and ventral nerve cord primordium. Orthologous to human MORF4L1 (mortality factor 4 like 1) and MORF4L2 (mortality factor 4 like 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See MRG15 in Genome Data Viewer
Location:
88E11-88E11; 3-56 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15276440..15278109, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11102162..11103831, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Zinc/iron regulated transporter-related protein 88E Neighboring gene Centrosomal protein 190kD Neighboring gene antisense RNA:CR46081 Neighboring gene uncharacterized protein Neighboring gene lethal (3) neo43 Neighboring gene Tropomyosin 1 Neighboring gene uncharacterized protein Neighboring gene Tropomyosin 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. FlyORF-TaDa allows rapid generation of new lines for in vivo cell-type-specific profiling of protein-DNA interactions in Drosophila melanogaster. Aughey GN, et al. G3 (Bethesda), 2021 Jan 18. PMID 33561239, Free PMC Article
  2. Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster. Zhang H, et al. Exp Gerontol, 2010 Nov. PMID 20600782, Free PMC Article
  3. Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2. Wallace HA, et al. G3 (Bethesda), 2015 Mar 9. PMID 25758823, Free PMC Article
  4. Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus. Messina G, et al. BMC Biol, 2022 Aug 3. PMID 35922843, Free PMC Article
  5. H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development. Zhu JY, et al. J Cardiovasc Dev Dis, 2023 Jul 18. PMID 37504562, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mrg15 is a subunit of the Ash1 complex, a stimulator of Ash1 enzymatic activity and a critical regulator of the TrxG protein function of Ash1 in Drosophila.
    Title: Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.
  2. Ash1 HMTase activity is activated by MRG15, a subunit of the identified Ash1 complex, and that this complex, rather than the Ash1 protein alone, is the active form of this H3K36 methyltransferase, both in vitro and in vivo.
    Title: Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC.
  3. Mrg15 interacts with Cap-H2 condensin subunit.
    Title: Maintenance of interphase chromosome compaction and homolog pairing in Drosophila is regulated by the condensin cap-h2 and its partner Mrg15.
  4. Drosophila DmMRG15 gene function is required for female fertility, larval survival and adult life span, and provides reagents that should be useful for further dissecting the role of DmMRG15 in cell proliferation and aging.
    Title: Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4K20me3 reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chromosome organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome separation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of histone methyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
MORF-related gene 15
Names
CG6363-PA
CG6363-PB
MRG15-PA
MRG15-PB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15276440..15278109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142185.2 → NP_650442.1  MORF-related gene 15, isoform A

    See identical proteins and their annotated locations for NP_650442.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VF99, Q9Y0I1
    Related
    FBpp0082579, FBtr0083125
    Conserved Domains (2) summary
    pfam05712
    Location:244 → 410
    MRG; MRG
    pfam11717
    Location:22 → 75
    Tudor-knot; RNA binding activity-knot of a chromodomain

  2. NM_001275659.1 → NP_001262588.1  MORF-related gene 15, isoform B

    See identical proteins and their annotated locations for NP_001262588.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHJ7
    Conserved Domains (2) summary
    pfam05712
    Location:249 → 415
    MRG; MRG
    pfam11717
    Location:22 → 75
    Tudor-knot; RNA binding activity-knot of a chromodomain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHJ7 A0A0B4KHJ7
Q9Y0I1.1 Q9Y0I1

Gene LinkOut

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