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ADAM11 ADAM metallopeptidase domain 11 [ Homo sapiens (human) ]

Gene ID: 4185, updated on 13-Mar-2020

Summary

Official Symbol
ADAM11provided by HGNC
Official Full Name
ADAM metallopeptidase domain 11provided by HGNC
Primary source
HGNC:HGNC:189
See related
Ensembl:ENSG00000073670 MIM:155120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDC
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Expression
Biased expression in brain (RPKM 9.4), heart (RPKM 3.1) and 5 other tissues See more
Orthologs

Genomic context

See ADAM11 in Genome Data Viewer
Location:
17q21.31
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (44758988..44781846)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42836405..42859214)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene DBF4 zinc finger B Neighboring gene ribosomal protein L6 pseudogene 26 Neighboring gene uncharacterized LOC107985044 Neighboring gene gap junction protein gamma 1 Neighboring gene HIG1 hypoxia inducible domain family member 1B Neighboring gene elongation factor Tu GTP binding domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding TAS
Traceable Author Statement
more info
PubMed 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 11
Names
ADAM 11
metalloproteinase-like, disintegrin-like, and cysteine-rich protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318933.2NP_001305862.1  disintegrin and metalloproteinase domain-containing protein 11 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate splice site in the 5' coding region resulting in a frameshift and the use of an alternate translation start site. The encoded isoform (3) has a shorter and distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AC005180, BC144550, BM557705, BM681070, CD630831, CD630842, CN418442
    Consensus CDS
    CCDS82139.1
    UniProtKB/TrEMBL
    B4DKD2
    Related
    ENSP00000443773.1, ENST00000535346.5
    Conserved Domains (4) summary
    smart00608
    Location:330468
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:39236
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:253327
    Disintegrin; Disintegrin
    pfam01421
    Location:39238
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
  2. NM_002390.6NP_002381.2  disintegrin and metalloproteinase domain-containing protein 11 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_002381.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB009675, AC005180, BC144550, BM557705, BM681070, CD630831, CD630842, CN418442
    Consensus CDS
    CCDS11486.1
    UniProtKB/Swiss-Prot
    O75078
    Related
    ENSP00000200557.6, ENST00000200557.11
    Conserved Domains (5) summary
    smart00608
    Location:530668
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453527
    Disintegrin; Disintegrin
    pfam01421
    Location:239438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:76188
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    44758988..44781846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257373.4XP_005257430.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X1

    Conserved Domains (5) summary
    smart00608
    Location:530668
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453527
    Disintegrin; Disintegrin
    pfam01421
    Location:239438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:76188
    Pep_M12B_propep; Reprolysin family propeptide
  2. XM_024450754.1XP_024306522.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X2

    Conserved Domains (3) summary
    smart00608
    Location:330468
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:253326
    Disintegrin; Disintegrin
    pfam01421
    Location:39238
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
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