ATPsynO ATP synthase, oligomycin sensitivity conferring protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ATPsynOprovided by FlyBase
Official Full Name: ATP synthase, oligomycin sensitivity conferring proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0016691
Locus tag: Dmel_CG4307
See related: AllianceGenome:FB:FBgn0016691
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ATPO; ATPO_DROME; CG4307; dATPsynO; Dmel\CG4307; oscp; Oscp; OSCP
Summary: Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis and proton transmembrane transport. Located in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; ganglia; gut section; and larval muscle cell. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 7. Orthologous to human ATP5PO (ATP synthase peripheral stalk subunit OSCP). [provided by Alliance of Genome Resources, May 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15265591..15266690)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11091313..11092412)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven mitochondrial ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven mitochondrial ATP synthesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
part_of proton-transporting ATP synthase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proton-transporting ATP synthase complex	NAS Non-traceable Author Statement more info	PubMed

Names: ATP synthase OSCP; ATP synthase oligomycin sensitivity conferral protein; ATPsynO-PA; CG4307-PA; F0/F1 ATP synthase OSCP; OLIGOMYCIN SENSITIVITY CONFERRING PROTEIN; oligimycin sensitive-conferring protein; oligomycin sensitivity conferring protein precursor; oligomycin sensitivity-conferring protein

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The following sections contain reference sequences that belong to a specific genome build. Explain