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Hsc70-4 Heat shock protein cognate 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41840, updated on 5-Aug-2018

Summary

Official Symbol
Hsc70-4provided by FlyBase
Official Full Name
Heat shock protein cognate 4provided by FlyBase
Primary source
FLYBASE:FBgn0266599
Locus tag
Dmel_CG4264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.237; Bap74; BAP74; bs17d06.y1; CG4264; chr3R:11070155..11070315; dhsc70; dHsp70; dHSP70; Dmel\CG4264; E(csp)1545; E(nd)195; Hsc-4; HSC-70; Hsc-70-4; hsc4; Hsc4; HSC4; Hsc4p; hsc70; Hsc70; HSC70; hsc70-4; HSC70-4; Hsp-c4; hsp70; Hsp70; HSP70; i190; l(3)03550; l(3)j7A4; l(3)L3929; mtHsp 70; Q3KN45_DROME; scd

Genomic context

See Hsc70-4 in Genome Data Viewer
Location:
88E4-88E4; 3-56 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15242687..15246614)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11068409..11072336)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene telomere fusion Neighboring gene Ammonium transporter Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity, coupled IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding involved in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
RNA interference IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to topologically incorrect protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
PubMed 
embryonic development via the syncytial blastoderm IMP
Inferred from Mutant Phenotype
more info
PubMed 
heterochromatin organization involved in chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
late endosomal microautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
membrane organization IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter secretion IPI
Inferred from Physical Interaction
more info
PubMed 
ovarian follicle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Z disc IDA
Inferred from Direct Assay
more info
PubMed 
catalytic step 2 spliceosome HDA PubMed 
cytoplasm HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perichromatin fibrils IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
precatalytic spliceosome HDA PubMed 

General protein information

Preferred Names
heat shock protein cognate 4
Names
Bap74
CG4264-PA
CG4264-PB
CG4264-PC
CG4264-PD
CG4264-PE
CG4264-PF
CG4264-PG
Hsc70-4-PA
Hsc70-4-PB
Hsc70-4-PC
Hsc70-4-PD
Hsc70-4-PE
Hsc70-4-PF
Hsc70-4-PG
heat shock 70-kDa protein cognate 4
heat shock cognate 4
heat shock cognate 70
heat shock cognate protein 4
heat shock cognate protein 70-4
heat shock protein 70
heat-shock protein 70
hsp cognate 4
scattered

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15242687..15246614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079632.6NP_524356.1  heat shock protein cognate 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524356.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11147
    UniProtKB/TrEMBL
    C7LA75
    Related
    FBpp0082516.1, FBtr0083057
    Conserved Domains (2) summary
    cd10233
    Location:6381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1612
    PTZ00009; heat shock 70 kDa protein; Provisional
  2. NM_001275657.1NP_001262586.1  heat shock protein cognate 4, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262586.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11147
    UniProtKB/TrEMBL
    C7LA75
    Related
    FBpp0307982.1, FBtr0337053
    Conserved Domains (2) summary
    cd10233
    Location:6381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1612
    PTZ00009; heat shock 70 kDa protein; Provisional
  3. NM_176502.2NP_788679.1  heat shock protein cognate 4, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788679.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11147
    UniProtKB/TrEMBL
    C7LA75
    Related
    FBpp0082514.1, FBtr0083055
    Conserved Domains (2) summary
    cd10233
    Location:6381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1612
    PTZ00009; heat shock 70 kDa protein; Provisional
  4. NM_169626.2NP_731988.1  heat shock protein cognate 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731988.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11147
    UniProtKB/TrEMBL
    C7LA75
    Related
    FBpp0082517.1, FBtr0083058
    Conserved Domains (2) summary
    cd10233
    Location:6381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1612
    PTZ00009; heat shock 70 kDa protein; Provisional
  5. NM_169627.2NP_731989.1  heat shock protein cognate 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731989.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11147
    UniProtKB/TrEMBL
    C7LA75
    Related
    FBpp0082518.1, FBtr0083059
    Conserved Domains (2) summary
    cd10233
    Location:6381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1612
    PTZ00009; heat shock 70 kDa protein; Provisional
  6. NM_169625.2NP_731987.1  heat shock protein cognate 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731987.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11147
    UniProtKB/TrEMBL
    C7LA75
    Related
    FBpp0082519.1, FBtr0083060
    Conserved Domains (2) summary
    cd10233
    Location:6381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1612
    PTZ00009; heat shock 70 kDa protein; Provisional
  7. NM_176503.2NP_788680.1  heat shock protein cognate 4, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788680.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11147
    UniProtKB/TrEMBL
    C7LA75
    Related
    FBpp0082515.1, FBtr0083056
    Conserved Domains (2) summary
    cd10233
    Location:6381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1612
    PTZ00009; heat shock 70 kDa protein; Provisional
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