Hsc70-4 Heat shock protein 70 cognate 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsc70-4provided by FlyBase
Official Full Name: Heat shock protein 70 cognate 4provided by FlyBase
Primary source: FLYBASE:FBgn0266599
Locus tag: Dmel_CG4264
See related: AllianceGenome:FB:FBgn0266599
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.237; Bap74; BAP74; bs17d06.y1; C7LA75; CG4264; chr3R:11070155..11070315; dhsc70; dHsp70; dHSP70; Dmel\CG4264; E(csp)1545; E(nd)195; Hsc-4; HSC-70; Hsc-70-4; hsc4; Hsc4; HSC4; Hsc4p; hsc70; Hsc70; HSC70; hsc70-4; HSC70-4; Hsc70.4; Hsp-c4; hsp70; Hsp70; HSP70; HSP70cB2; i190; l(3)03550; l(3)j7A4; l(3)L3929; mtHsp 70; Q3KN45_DROME; scd
Summary: Enables chaperone binding activity. Involved in several processes, including axon development; late endosomal microautophagy; and positive regulation of small RNA loading onto RISC. Located in cytoplasm and perichromatin fibrils. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Colocalizes with Z disc and mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval neuromuscular junction; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); neurodegenerative disease (multiple); and schizophrenia (multiple). Orthologous to several human genes including HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 88E4-88E4; 3-56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.46	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15242687..15246614)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11068409..11072336)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

molecular chaperone Hsp70 and Hsc70 play an indispensable role during Drosophila eye development.
Title: Molecular Chaperone Hsp70 and Its Constitutively Active Form Hsc70 Play an Indispensable Role During Eye Development of Drosophila melanogaster.
Post-transcriptional inhibition of Hsc70-4 expression leads to synaptic vesicle cycling defects in multiple models of amyotrophic lateral sclerosis.
Title: Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.
Hsc70-4 controls rejuvenation of the synaptic protein pool in a dual way: either by refolding proteins together with Sgt, or by targeting them for degradation by facilitating endosomal microautophagy based on its membrane deforming activity.
Title: Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy.
interference with its endogenous activity accelerated alpha-synuclein toxicity in Drosophila model of Parkinson's disease
Title: Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Oh99 (e-PCR)
- UniSTS:265030

Ot99 (e-PCR)
- UniSTS:265030

Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein-folding chaperone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RISC complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to topologically incorrect protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late endosomal microautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in membrane bending	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with Z disc	IDA Inferred from Direct Assay more info	PubMed
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
colocalizes_with mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perichromatin fibrils	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed

General protein information

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Preferred Names: heat shock protein 70 cognate 4

Names: 70 kDa heat shock protein, cytosolic B 2; Bap74; CG4264-PA; CG4264-PB; CG4264-PC; CG4264-PD; CG4264-PE; CG4264-PF; CG4264-PG; Hsc70-4-PA; Hsc70-4-PB; Hsc70-4-PC; Hsc70-4-PD; Hsc70-4-PE; Hsc70-4-PF; Hsc70-4-PG; heat shock 70 kDa protein cognate 4; heat shock 70-kDa protein cognate 4; heat shock cognate 4; heat shock cognate 70; heat shock cognate protein 4; heat shock cognate protein 70-4; heat shock protein 70; heat shock protein cognate 4; heat-shock protein 70; hsp cognate 4; scattered

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

15242687..15246614

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079632.6 → NP_524356.1 heat shock protein 70 cognate 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524356.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11147, Q3KN45, Q8SXQ4, Q9VFB0

UniProtKB/TrEMBL

C7LA75

Related

FBpp0082516, FBtr0083057

Conserved Domains (2) summary

cd10233
Location:6 → 381

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:1 → 612

PTZ00009; heat shock 70 kDa protein; Provisional
NM_001275657.1 → NP_001262586.1 heat shock protein 70 cognate 4, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262586.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11147, Q3KN45, Q8SXQ4, Q9VFB0

UniProtKB/TrEMBL

C7LA75

Related

FBpp0307982, FBtr0337053

Conserved Domains (2) summary

cd10233
Location:6 → 381

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:1 → 612

PTZ00009; heat shock 70 kDa protein; Provisional
NM_176502.2 → NP_788679.1 heat shock protein 70 cognate 4, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788679.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11147, Q3KN45, Q8SXQ4, Q9VFB0

UniProtKB/TrEMBL

C7LA75

Related

FBpp0082514, FBtr0083055

Conserved Domains (2) summary

cd10233
Location:6 → 381

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:1 → 612

PTZ00009; heat shock 70 kDa protein; Provisional
NM_169626.2 → NP_731988.1 heat shock protein 70 cognate 4, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731988.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11147, Q3KN45, Q8SXQ4, Q9VFB0

UniProtKB/TrEMBL

C7LA75

Related

FBpp0082517, FBtr0083058

Conserved Domains (2) summary

cd10233
Location:6 → 381

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:1 → 612

PTZ00009; heat shock 70 kDa protein; Provisional
NM_169627.2 → NP_731989.1 heat shock protein 70 cognate 4, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731989.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11147, Q3KN45, Q8SXQ4, Q9VFB0

UniProtKB/TrEMBL

C7LA75

Related

FBpp0082518, FBtr0083059

Conserved Domains (2) summary

cd10233
Location:6 → 381

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:1 → 612

PTZ00009; heat shock 70 kDa protein; Provisional
NM_169625.2 → NP_731987.1 heat shock protein 70 cognate 4, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731987.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11147, Q3KN45, Q8SXQ4, Q9VFB0

UniProtKB/TrEMBL

C7LA75

Related

FBpp0082519, FBtr0083060

Conserved Domains (2) summary

cd10233
Location:6 → 381

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:1 → 612

PTZ00009; heat shock 70 kDa protein; Provisional
NM_176503.2 → NP_788680.1 heat shock protein 70 cognate 4, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788680.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P11147, Q3KN45, Q8SXQ4, Q9VFB0

UniProtKB/TrEMBL

C7LA75

Related

FBpp0082515, FBtr0083056

Conserved Domains (2) summary

cd10233
Location:6 → 381

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:1 → 612

PTZ00009; heat shock 70 kDa protein; Provisional