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TMPRSS6 transmembrane serine protease 6 [ Gallus gallus (chicken) ]

Gene ID: 418046, updated on 13-Apr-2026
Official Symbol
TMPRSS6provided by CGNC
Official Full Name
transmembrane serine protease 6provided by CGNC
Primary source
CGNC:9483
See related
Ensembl:ENSGALG00010014778
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See TMPRSS6 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (51513075..51532907)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (51809798..51829609)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 6 Neighboring gene potassium channel tetramerization domain containing 17 Neighboring gene interleukin 2 receptor subunit beta Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene thiosulfate sulfurtransferase

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
transmembrane protease serine 6
Names
transmembrane protease, serine 6

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    51513075..51532907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004937767.5 → XP_004937824.4  transmembrane protease serine 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YPS2, A0A8V0YWI1
    Conserved Domains (3) summary
    cd00041
    Location:311 → 426
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:435 → 465
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:553 → 785
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_004937765.5 → XP_004937822.4  transmembrane protease serine 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YPS2, A0A8V0YWI1
    Related
    ENSGALP00010020651.1, ENSGALT00010035541.1
    Conserved Domains (3) summary
    cd00041
    Location:311 → 426
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:435 → 465
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:553 → 785
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_025155403.3 → XP_025011171.2  transmembrane protease serine 6 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YPR8, A0A8V0YPS2
    Related
    ENSGALP00010020649.1, ENSGALT00010035537.1

  4. XM_025155406.3 → XP_025011174.2  transmembrane protease serine 6 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YPS2
    Related
    ENSGALP00010020647.1, ENSGALT00010035534.1
    Conserved Domains (3) summary
    cd00041
    Location:319 → 434
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:443 → 473
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:561 → 793
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. XM_004937766.5 → XP_004937823.4  transmembrane protease serine 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YPS2, A0A8V0YWI1
    Conserved Domains (3) summary
    cd00041
    Location:311 → 426
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:435 → 465
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:553 → 785
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    51809798..51829609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040660690.2 → XP_040516624.1  transmembrane protease serine 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YPS2, A0A8V0YWI1
    Conserved Domains (3) summary
    cd00041
    Location:311 → 426
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:435 → 465
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:553 → 785
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_040660689.1 → XP_040516623.1  transmembrane protease serine 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YPS2, A0A8V0YWI1
    Conserved Domains (3) summary
    cd00041
    Location:311 → 426
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:435 → 465
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:553 → 785
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_040660686.2 → XP_040516620.1  transmembrane protease serine 6 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YPR8, A0A8V0YPS2

  4. XM_040660687.2 → XP_040516621.1  transmembrane protease serine 6 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YPS2
    Conserved Domains (3) summary
    cd00041
    Location:319 → 434
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:443 → 473
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:561 → 793
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. XM_040660688.2 → XP_040516622.1  transmembrane protease serine 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YPS2, A0A8V0YWI1
    Conserved Domains (3) summary
    cd00041
    Location:311 → 426
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:435 → 465
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:553 → 785
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version

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