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MCM7 minichromosome maintenance complex component 7 [ Homo sapiens (human) ]

Gene ID: 4176, updated on 13-Mar-2020

Summary

Official Symbol
MCM7provided by HGNC
Official Full Name
minichromosome maintenance complex component 7provided by HGNC
Primary source
HGNC:HGNC:6950
See related
Ensembl:ENSG00000166508 MIM:600592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 53.3), lymph node (RPKM 33.2) and 24 other tissues See more
Orthologs

Genomic context

See MCM7 in Genome Data Viewer
Location:
7q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100092728..100101397, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99690351..99699563, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 21 Neighboring gene zinc finger protein 3 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 106b Neighboring gene microRNA 25 Neighboring gene microRNA 93 Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 7 (MCM7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of minichromosome maintenance complex component 7 (MCM7) in the nucleoli of Jurkat T-cells PubMed
tat Interaction of HIV-1 Tat with MCM7 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA binding TAS
Traceable Author Statement
more info
PubMed 
contributes_to DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
MCM complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear chromosome, telomeric region HDA PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM7
Names
CDC47 homolog
homolog of S. cerevisiae Cdc47
minichromosome maintenance deficient 7
protein phosphatase 1, regulatory subunit 104
NP_001265524.1
NP_005907.3
NP_877577.1
XP_005250405.1
XP_016867706.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278595.2NP_001265524.1  DNA replication licensing factor MCM7 isoform 2

    See identical proteins and their annotated locations for NP_001265524.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional internal segment, which results in translation initiation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC073842
    Consensus CDS
    CCDS5684.1
    UniProtKB/Swiss-Prot
    P33993
    UniProtKB/TrEMBL
    C6EMX8
    Related
    ENSP00000483795.1, ENST00000621318.4
    Conserved Domains (2) summary
    smart00350
    Location:1465
    MCM; minichromosome maintenance proteins
    cl21455
    Location:200339
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_005916.5NP_005907.3  DNA replication licensing factor MCM7 isoform 1

    See identical proteins and their annotated locations for NP_005907.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC073842
    Consensus CDS
    CCDS5683.1
    UniProtKB/Swiss-Prot
    P33993
    UniProtKB/TrEMBL
    A0A0S2Z4A5, C6EMX8
    Related
    ENSP00000307288.5, ENST00000303887.10
    Conserved Domains (3) summary
    smart00350
    Location:145641
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:12165
    MCM_N; MCM N-terminal domain
    cl21455
    Location:376515
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_182776.2NP_877577.1  DNA replication licensing factor MCM7 isoform 2

    See identical proteins and their annotated locations for NP_877577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 5' end, contains an additional internal segment, and initiates translation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK055379, AK226175, DA253520
    Consensus CDS
    CCDS5684.1
    UniProtKB/Swiss-Prot
    P33993
    Related
    ENSP00000346171.3, ENST00000354230.7
    Conserved Domains (2) summary
    smart00350
    Location:1465
    MCM; minichromosome maintenance proteins
    cl21455
    Location:200339
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100092728..100101397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012217.2XP_016867706.1  DNA replication licensing factor MCM7 isoform X1

    Conserved Domains (3) summary
    smart00350
    Location:38534
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:1158
    MCM_N; MCM N-terminal domain
    cl21455
    Location:269408
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005250348.3XP_005250405.1  DNA replication licensing factor MCM7 isoform X1

    Conserved Domains (3) summary
    smart00350
    Location:38534
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:1158
    MCM_N; MCM N-terminal domain
    cl21455
    Location:269408
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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