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MCM6 minichromosome maintenance complex component 6 [ Homo sapiens (human) ]

Gene ID: 4175, updated on 12-Sep-2021

Summary

Official Symbol
MCM6provided by HGNC
Official Full Name
minichromosome maintenance complex component 6provided by HGNC
Primary source
HGNC:HGNC:6949
See related
Ensembl:ENSG00000076003 MIM:601806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mis5; P105MCM; MCG40308
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
Expression
Broad expression in lymph node (RPKM 19.9), bone marrow (RPKM 13.7) and 24 other tissues See more
Orthologs
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Genomic context

See MCM6 in Genome Data Viewer
Location:
2q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (135839626..135876443, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (136597196..136634013, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985946 Neighboring gene UBX domain protein 4 Neighboring gene lactase Neighboring gene LCT antisense RNA 1 Neighboring gene MANEAL pseudogene 1 Neighboring gene aspartyl-tRNA synthetase 1 Neighboring gene DARS1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 6 (MCM6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of minichromosome maintenance complex component 6 (MCM6) in the nucleoli of Jurkat T-cells PubMed
tat Interaction of HIV-1 Tat with MCM6 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
Vpr vpr HIV-1 Vpr downregulates MCM6 in HeLa cells within 12 hours of exposure PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with minichromosome maintenance complex component 6 (MCM6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to single-stranded 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of CMG complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM6
Names
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
minichromosome maintenance deficient (mis5, S. pombe) 6
NP_005906.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008958.1 RefSeqGene

    Range
    4999..41816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005915.6NP_005906.2  DNA replication licensing factor MCM6

    See identical proteins and their annotated locations for NP_005906.2

    Status: REVIEWED

    Source sequence(s)
    AA577398, BC020268, BC032374, CN389677, DA521248
    Consensus CDS
    CCDS2179.1
    UniProtKB/Swiss-Prot
    Q14566
    Related
    ENSP00000264156.2, ENST00000264156.3
    Conserved Domains (3) summary
    smart00350
    Location:119657
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:27114
    MCM_N; MCM N-terminal domain
    pfam18263
    Location:713817
    MCM6_C; MCM6 C-terminal winged-helix domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    135839626..135876443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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