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ERN1 endoplasmic reticulum to nucleus signaling 1 [ Gallus gallus (chicken) ]

Gene ID: 417414, updated on 3-Apr-2024

Summary

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Symbol
ERN1provided by CGNC
Full Name
endoplasmic reticulum to nucleus signaling 1provided by CGNC
Primary source
CGNC:50503
See related
Ensembl:ENSGALG00010029610
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
24
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 18 NC_052549.1 (7388504..7422209, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 18 NC_052590.1 (6983676..7017051, complement)

Chromosome 18 - NC_052549.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417296 Neighboring gene rhomboid like 3 Neighboring gene C17orf75 homolog Neighboring gene zinc finger protein 207 Neighboring gene uncharacterized LOC121107129 Neighboring gene uncharacterized LOC107052236 Neighboring gene small nucleolar RNA SNORD104 Neighboring gene small nucleolar RNA SNORA76

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of IRE1-TRAF2-ASK1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase/endoribonuclease IRE1
Names
serine/threonine-protein kinase/endoribonuclease IRE1-like
NP_001272428.2
XP_015135376.2
XP_024997370.1
XP_024997372.1
XP_040505432.1
XP_046757990.1
XP_046785368.1
XP_046785369.1
XP_046785370.1
XP_046785371.1
XP_046785372.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285499.2 → NP_001272428.2  serine/threonine-protein kinase/endoribonuclease IRE1 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000317
    UniProtKB/TrEMBL
    A0A8V1AE45
    Related
    ENSGALP00010044286.1, ENSGALT00010071596.1
    Conserved Domains (3) summary
    cd09769
    Location:31 → 299
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:829 → 954
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:561 → 826
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052549.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    7388504..7422209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025141604.3 → XP_024997372.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

    UniProtKB/TrEMBL
    A0A8V1AJH4
    Conserved Domains (3) summary
    cd13982
    Location:443 → 708
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 181
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
    cl15368
    Location:711 → 783
    RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L

  2. XM_025141602.3 → XP_024997370.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

    UniProtKB/TrEMBL
    A0A8V1AE45
    Conserved Domains (3) summary
    cd09769
    Location:10 → 278
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd13982
    Location:540 → 805
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl15368
    Location:808 → 880
    RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L

  3. XM_040649498.2 → XP_040505432.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

    UniProtKB/TrEMBL
    A0A8V1AE45, A0A8V1AJH7
    Related
    ENSGALP00010044288.1, ENSGALT00010071598.1
    Conserved Domains (3) summary
    cd09769
    Location:10 → 278
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:808 → 933
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:540 → 805
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

  4. XM_015279890.4 → XP_015135376.2  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1

    UniProtKB/TrEMBL
    A0A8V1AE45
    Conserved Domains (3) summary
    cd09769
    Location:31 → 299
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd13982
    Location:561 → 826
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl15368
    Location:829 → 901
    RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L

  5. XM_046902034.1 → XP_046757990.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052590.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    6983676..7017051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046929415.1 → XP_046785371.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

  2. XM_046929413.1 → XP_046785369.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

  3. XM_046929414.1 → XP_046785370.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

  4. XM_046929412.1 → XP_046785368.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1

  5. XM_046929416.1 → XP_046785372.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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