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MCM4 minichromosome maintenance complex component 4 [ Homo sapiens (human) ]

Gene ID: 4173, updated on 5-Jul-2020

Summary

Official Symbol
MCM4provided by HGNC
Official Full Name
minichromosome maintenance complex component 4provided by HGNC
Primary source
HGNC:HGNC:6947
See related
Ensembl:ENSG00000104738 MIM:602638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 21.3), bone marrow (RPKM 19.5) and 24 other tissues See more
Orthologs

Genomic context

See MCM4 in Genome Data Viewer
Location:
8q11.21
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (47960941..47978160)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (48872763..48890720)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene uncharacterized LOC105375818 Neighboring gene origin of replication upstream of MCM4 Neighboring gene uncharacterized TCONS_00068220 Neighboring gene RNA, U6 small nuclear 519, pseudogene Neighboring gene ubiquitin conjugating enzyme E2 V2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 4 (MCM4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33310

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
DNA replication TAS
Traceable Author Statement
more info
 
DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nuclear chromosome, telomeric region HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM4
Names
homolog of S. pombe cell devision cycle 21
minichromosome maintenance deficient 4
NP_005905.2
NP_877423.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032967.1 RefSeqGene

    Range
    5739..22958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1239

mRNA and Protein(s)

  1. NM_005914.4NP_005905.2  DNA replication licensing factor MCM4

    See identical proteins and their annotated locations for NP_005905.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents a longer transcript and differs in the 5' UTR, as compared to variant 2. Both variants encode the same protein.
    Source sequence(s)
    AC021236, AK296913, BC031061, BF793151, BQ689703
    Consensus CDS
    CCDS6143.1
    UniProtKB/Swiss-Prot
    P33991
    UniProtKB/TrEMBL
    B4DLA6
    Related
    ENSP00000262105.2, ENST00000262105.6
    Conserved Domains (3) summary
    smart00350
    Location:267770
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:166287
    MCM_N; MCM N-terminal domain
    cl21455
    Location:505644
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_182746.3NP_877423.1  DNA replication licensing factor MCM4

    See identical proteins and their annotated locations for NP_877423.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, when compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AC021236, AK022899, BC031061, BQ689703
    Consensus CDS
    CCDS6143.1
    UniProtKB/Swiss-Prot
    P33991
    UniProtKB/TrEMBL
    B3KMX0
    Related
    ENSP00000496964.1, ENST00000649973.1
    Conserved Domains (3) summary
    smart00350
    Location:267770
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:166287
    MCM_N; MCM N-terminal domain
    cl21455
    Location:505644
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    47960941..47978160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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