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MCM4 minichromosome maintenance complex component 4 [ Homo sapiens (human) ]

Gene ID: 4173, updated on 6-Oct-2024

Summary

Official Symbol
MCM4provided by HGNC
Official Full Name
minichromosome maintenance complex component 4provided by HGNC
Primary source
HGNC:HGNC:6947
See related
Ensembl:ENSG00000104738 MIM:602638; AllianceGenome:HGNC:6947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 21.3), bone marrow (RPKM 19.5) and 24 other tissues See more
Orthologs
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Genomic context

See MCM4 in Genome Data Viewer
Location:
8q11.21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (47960941..47978160)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (48337189..48354408)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (48873501..48890720)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:48649750-48650688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48664855-48665355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27329 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:48678117-48678684 Neighboring gene CCAAT enhancer binding protein delta Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:48734487-48735248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48737843-48738343 Neighboring gene Sharpr-MPRA regulatory region 7649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48770411-48770910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27330 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:48836071-48836571 Neighboring gene uncharacterized LOC105375818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48867403-48867904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19177 Neighboring gene origin of replication upstream of MCM4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19179 Neighboring gene RNA, U6 small nuclear 519, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48909281-48909780 Neighboring gene UBE2V2 antisense RNA 1 Neighboring gene ubiquitin conjugating enzyme E2 V2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 4 (MCM4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC33310

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of CMG complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of CMG complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MCM complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromosome, telomeric region HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM4
Names
homolog of S. pombe cell devision cycle 21
minichromosome maintenance deficient 4
NP_005905.2
NP_877423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032967.1 RefSeqGene

    Range
    5739..22958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1239

mRNA and Protein(s)

  1. NM_005914.4NP_005905.2  DNA replication licensing factor MCM4

    See identical proteins and their annotated locations for NP_005905.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents a longer transcript and differs in the 5' UTR, as compared to variant 2. Both variants encode the same protein.
    Source sequence(s)
    AC021236, AK296913, BC031061, BF793151, BQ689703
    Consensus CDS
    CCDS6143.1
    UniProtKB/Swiss-Prot
    P33991, Q8NEH1, Q99658
    UniProtKB/TrEMBL
    B3KMX0
    Related
    ENSP00000262105.2, ENST00000262105.6
    Conserved Domains (2) summary
    smart00350
    Location:267770
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:163263
    MCM_N; MCM N-terminal domain
  2. NM_182746.3NP_877423.1  DNA replication licensing factor MCM4

    See identical proteins and their annotated locations for NP_877423.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, when compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AC021236, AK022899, BC031061, BQ689703
    Consensus CDS
    CCDS6143.1
    UniProtKB/Swiss-Prot
    P33991, Q8NEH1, Q99658
    UniProtKB/TrEMBL
    B3KMX0
    Related
    ENSP00000496964.1, ENST00000649973.1
    Conserved Domains (2) summary
    smart00350
    Location:267770
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:163263
    MCM_N; MCM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    47960941..47978160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    48337189..48354408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)