TLR4 toll like receptor 4 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: TLR4provided by CGNC
Official Full Name: toll like receptor 4provided by CGNC
Primary source: CGNC:5282
See related: Ensembl:ENSGALG00010028914
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	17	NC_052548.1 (4245618..4251245)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	17	NC_052589.1 (3655209..3660835)

Chromosome 17 - NC_052548.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The anti-inflammatory effect of lutein in broilers is mediated by regulating Toll-like receptor 4/myeloid-differentiation-factor 88 signaling pathway.
Title: The anti-inflammatory effect of lutein in broilers is mediated by regulating Toll-like receptor 4/myeloid-differentiation-factor 88 signaling pathway.
TLR2 and TLR4 molecules and antigen-presenting cell compositions in cecal tonsils of broiler chicks (Gallus gallus domesticus) in the first two weeks of the post-hatch period.
Title: TLR2 and TLR4 molecules and antigen-presenting cell compositions in cecal tonsils of broiler chicks (Gallus gallus domesticus) in the first two weeks of the post-hatch period.
ulvan may be a new ligand for TLR2 and TLR4; and that they regulate heterophil activation in slightly different manner.
Title: Ulvan Activates Chicken Heterophils and Monocytes Through Toll-Like Receptor 2 and Toll-Like Receptor 4.
From 1 d of age, TLR4 positivity was found in the spleen in diffuse granular form. The cells showing intense TLR4 positivity were observed in periellipsoidal lymphoid tissue in 4-d-old chicks.
Title: Distribution of TLR4 and MHC class II molecules of the spleen in broiler chicks treated with and without LPS in the first 2 weeks of the post-hatch period.
The intra-peritoneal administration of lipopolysaccharide leads to TLR4-mediated destruction of the tracheal epithelium and pulmonary inflammation along with increased SIgA expression in the tracheal mucosa.
Title: Effects of lipopolysaccharide on the histomorphology and expression of toll-like receptor 4 in the chicken trachea and lung.
Enterococcus faecium probiotic protects chickens from Campylobacter jejuni infection by modulating the expression of TKR4, TLR21, and immune response proteins.
Title: TLR4 and TLR21 expression, MIF, IFN-β, MD-2, CD14 activation, and sIgA production in chickens administered with EFAL41 strain challenged with Campylobacter jejuni.
genetic variants in TLR4 loci 903 and 1832 are associated with resistance to Salmonella enteritidis infection in SPF White Leghorns
Title: Difference in resistance to Salmonella enteritidis infection among allelic variants of TLR4 (903, 1832) in SPF chickens.
The TLR4 gene is polymorphic among different chicken breeds.
Title: Polymorphisms of chicken TLR3 and 7 in different breeds.
TLR4 is constitutively expressed by epithelial cells in the thymus, suggesting it may participate in thymic development by inducing factors affecting its development.
Title: TLR4 is constitutively expressed in chick thymic epithelial cells.
Results show that the Toll-like receptors TLR4 and TLR7 that the mRNA expression levels in the spleen were lower in the 300, 600, and 900 mg/kg groups than those in the control group.
Title: Downregulation of TLR4 and 7 mRNA expression levels in broiler's spleen caused by diets supplemented with nickel chloride.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lipopolysaccharide immune receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: toll-like receptor 4

NP_001025864.2

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030693.2 → NP_001025864.2 toll-like receptor 4 precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000308

UniProtKB/TrEMBL

A0A1L4FM41, A0A1L4FM55, C4PCF3, I3QHT1

Related

ENSGALP00010043078.1, ENSGALT00010069952.1

Conserved Domains (5) summary

TIGR00864
Location:559 → 646

PCC; polycystin cation channel protein

smart00255
Location:688 → 825

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:63 → 593

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:360 → 376

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:60 → 83

LRR_RI; leucine-rich repeat [structural motif]