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MCM2 minichromosome maintenance complex component 2 [ Homo sapiens (human) ]

Gene ID: 4171, updated on 7-Jun-2020

Summary

Official Symbol
MCM2provided by HGNC
Official Full Name
minichromosome maintenance complex component 2provided by HGNC
Primary source
HGNC:HGNC:6944
See related
Ensembl:ENSG00000073111 MIM:116945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BM28; CCNL1; CDCL1; cdc19; DFNA70; D3S3194; MITOTIN
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
Expression
Broad expression in bone marrow (RPKM 27.3), lymph node (RPKM 14.9) and 23 other tissues See more
Orthologs

Genomic context

See MCM2 in Genome Data Viewer
Location:
3q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (127598411..127622436)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127317200..127341279)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein adipocyte associated 1 Neighboring gene microRNA 6825 Neighboring gene microRNA 7976 Neighboring gene uncharacterized LOC107986126 Neighboring gene podocalyxin like 2 Neighboring gene ankyrin repeat and BTB domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of minichromosome maintenance complex component 2 (MCM2) in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0030, MGC10606

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
histone binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nuclear chromosome, telomeric region HDA PubMed 
nuclear origin of replication recognition complex IEA
Inferred from Electronic Annotation
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA replication licensing factor MCM2
Names
cell devision cycle-like 1
cyclin-like 1
minichromosome maintenance deficient 2 (mitotin)
minichromosome maintenance protein 2 homolog
nuclear protein BM28
NP_004517.2
XP_024309299.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050771.1 RefSeqGene

    Range
    5055..29080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004526.4NP_004517.2  DNA replication licensing factor MCM2

    See identical proteins and their annotated locations for NP_004517.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    BC007938, DB100427
    Consensus CDS
    CCDS3043.1
    UniProtKB/Swiss-Prot
    P49736
    Related
    ENSP00000265056.7, ENST00000265056.12
    Conserved Domains (3) summary
    smart00350
    Location:291803
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:73182
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:199287
    MCM_N; MCM N-terminal domain

RNA

  1. NR_073375.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK299934, BC000300
    Related
    ENST00000474964.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    127598411..127622436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453531.1XP_024309299.1  DNA replication licensing factor MCM2 isoform X1

    Conserved Domains (3) summary
    smart00350
    Location:282794
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:64173
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:190278
    MCM_N; MCM N-terminal domain
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