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Kots Kotsubu [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41702, updated on 11-Apr-2024

Summary

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Official Symbol
Kotsprovided by FlyBase
Official Full Name
Kotsubuprovided by FlyBase
Primary source
FLYBASE:FBgn0038191
Locus tag
Dmel_CG9925
See related
AllianceGenome:FB:FBgn0038191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9925; Dmel\CG9925; kots
Summary
Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Predicted to be active in P granule. Is expressed in several structures, including fat body/gonad primordium; germline cell; and gonad. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Kots in Genome Data Viewer
Location:
88A3-88A3; 3-54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13960712..13964174, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9786434..9789896, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene stable intronic sequence RNA CR46363 Neighboring gene Inositol polyphosphate 1-phosphatase Neighboring gene Origin recognition complex subunit 2 Neighboring gene roadkill

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intron retention in the Drosophila melanogaster Rieske Iron Sulphur Protein gene generated a new protein. Gontijo AM, et al. Nat Commun, 2011. PMID 21610726, Free PMC Article
  2. oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction. Kanke M, et al. RNA, 2015 Jun. PMID 25862242, Free PMC Article
  3. Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila. Hekmat-Scafe DS, et al. J Neurosci, 2006 Aug 30. PMID 16943550, Free PMC Article
  4. The Tudor Domain-Containing Protein, Kotsubu (CG9925), Localizes to the Nuage and Functions in piRNA Biogenesis in D. melanogaster. Lim LX, et al. Front Mol Biosci, 2022. PMID 35425810, Free PMC Article
  5. Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks. Chaouch A, et al. Mol Cell, 2021 Dec 2. PMID 34739871, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in P granule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of innate immune response HMP PubMed 
involved_in retrotransposon silencing by mRNA destabilization IC
Inferred by Curator
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kotsubu
Names
CG9925-PA
Kots-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13960712..13964174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142067.3 → NP_650324.1  kotsubu [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650324.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3N7, Q9VFP5
    Related
    FBpp0082339
    Conserved Domains (3) summary
    cd04508
    Location:779 → 825
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:109 → 225
    TUDOR; Tudor domain
    pfam01753
    Location:9 → 44
    zf-MYND; MYND finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T3N7 Q8T3N7
Q9VFP5 Q9VFP5

Gene LinkOut

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