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Adgf-C Adenosine deaminase-related growth factor C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41680, updated on 9-Dec-2024

Summary

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Official Symbol
Adgf-Cprovided by FlyBase
Official Full Name
Adenosine deaminase-related growth factor Cprovided by FlyBase
Primary source
FLYBASE:FBgn0038173
Locus tag
Dmel_CG9345
See related
AllianceGenome:FB:FBgn0038173
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ADGF-C; adgfc; AdgfC; CG9345; Dmel\CG9345
Summary
Predicted to enable adenosine deaminase activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Adgf-C in Genome Data Viewer
Location:
87F12-87F12; 3-54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13706757..13709129)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9532479..9534851)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene flyers-cup Neighboring gene neither inactivation nor afterpotential B Neighboring gene Adenosine deaminase-related growth factor D Neighboring gene Arginine phosphatase Neighboring gene primo-1 Neighboring gene primo-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of the ADGF multigene family by homologous recombination and gene conversion in Drosophila. Dolezal T, et al. Genetics, 2003 Oct. PMID 14573477, Free PMC Article
  2. Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine. Zurovec M, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11904370, Free PMC Article
  3. Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death. Zuberova M, et al. Dis Model Mech, 2010 Nov-Dec. PMID 20940317
  4. The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins. Charlab R, et al. Gene, 2001 Apr 4. PMID 11311551
  5. Characterization of the adenosine deaminase-related growth factor (ADGF) gene family in Drosophila. Maier SA, et al. Gene, 2001 Dec 12. PMID 11738815

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenosine deaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in adenosine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in inosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
adenosine deaminase-related growth factor C
Names
Adgf-C-PA
CG9345-PA
NP_650308.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13706757..13709129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142051.3 → NP_650308.3  adenosine deaminase-related growth factor C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650308.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WS97, Q9VFS0
    Related
    FBpp0082289
    Conserved Domains (3) summary
    cd01321
    Location:78 → 493
    ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
    TIGR01431
    Location:25 → 501
    adm_rel; adenosine deaminase-related growth factor
    pfam08451
    Location:5 → 98
    A_deaminase_N; Adenosine/AMP deaminase N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VFS0 Q9VFS0

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