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CARD11 caspase recruitment domain family member 11 [ Gallus gallus (chicken) ]

Gene ID: 416476, updated on 5-Sep-2025
Official Symbol
CARD11provided by CGNC
Official Full Name
caspase recruitment domain family member 11provided by CGNC
Primary source
CGNC:50263
See related
Ensembl:ENSGALG00010017184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CARMA1
Orthologs
human mouse all
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See CARD11 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
26
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (3433403..3473539, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (3431639..3471796, complement)

Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene G protein subunit alpha 12 Neighboring gene sidekick cell adhesion molecule 1 Neighboring gene cytochrome P450 family 3 subfamily A member 4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity. Moreno-García ME, et al. Mol Cell Biol, 2010 Feb. PMID 20008554, Free PMC Article
  2. IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells. Shinohara H, et al. J Exp Med, 2007 Dec 24. PMID 18086859, Free PMC Article
  3. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
  4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. found that antigen receptor-activated CARMA1 underwent lysine 48 (K48) polyubiquitination and proteasome-dependent degradation.
    Title: MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
  2. IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells
    Title: IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
caspase recruitment domain-containing protein 11

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006161.4 → NP_001006161.3  caspase recruitment domain-containing protein 11

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000257
    UniProtKB/TrEMBL
    Q5F3W0
    Related
    ENSGALP00010024287.1, ENSGALT00010041469.1
    Conserved Domains (5) summary
    COG1196
    Location:129 → 419
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd08808
    Location:24 → 109
    CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins
    cl00117
    Location:716 → 768
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl17036
    Location:809 → 858
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:1025 → 1159
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3433403..3473539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040647347.1 → XP_040503281.1  caspase recruitment domain-containing protein 11 isoform X2

    UniProtKB/TrEMBL
    Q5F3W0
    Conserved Domains (5) summary
    COG1196
    Location:180 → 470
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd08808
    Location:75 → 160
    CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins
    cl00117
    Location:766 → 818
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl17036
    Location:859 → 908
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:1075 → 1209
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. XM_015294162.3 → XP_015149648.2  caspase recruitment domain-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    Q5F3W0
    Conserved Domains (5) summary
    COG1196
    Location:180 → 470
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd08808
    Location:75 → 160
    CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins
    cl00117
    Location:767 → 819
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl17036
    Location:860 → 909
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:1076 → 1210
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  3. XM_040647348.2 → XP_040503282.1  caspase recruitment domain-containing protein 11 isoform X3

    UniProtKB/TrEMBL
    Q5F3W0
    Conserved Domains (5) summary
    COG1196
    Location:120 → 410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd08808
    Location:15 → 100
    CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins
    cl00117
    Location:707 → 759
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl17036
    Location:800 → 849
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:1016 → 1150
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3431639..3471796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046927348.1 → XP_046783304.1  caspase recruitment domain-containing protein 11 isoform X2

    UniProtKB/TrEMBL
    Q5F3W0

  2. XM_046927347.1 → XP_046783303.1  caspase recruitment domain-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    Q5F3W0

  3. XM_046927349.1 → XP_046783305.1  caspase recruitment domain-containing protein 11 isoform X3

    UniProtKB/TrEMBL
    Q5F3W0
Nucleotide Protein Strain
Heading Accession and Version

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