U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

P4HA2 prolyl 4-hydroxylase subunit alpha 2 [ Gallus gallus (chicken) ]

Gene ID: 416326, updated on 13-Apr-2026
Symbol
P4HA2provided by CGNC
Full Name
prolyl 4-hydroxylase subunit alpha 2provided by CGNC
Primary source
CGNC:50226
See related
Ensembl:ENSGALG00010016225
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See P4HA2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (16344620..16368673, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (16356221..16380367, complement)

Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene interleukin 3 Neighboring gene interleukin-like Neighboring gene uncharacterized LOC121106692 Neighboring gene PDZ and LIM domain 4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
prolyl 4-hydroxylase subunit alpha-2
Names
4-PH alpha-2
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II
procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2
prolyl 4-hydroxylase alpha-2 subunit
prolyl 4-hydroxylase, alpha polypeptide II
NP_001006155.1
XP_015149508.2
XP_015149509.2
XP_015149512.2
XP_025010627.2
XP_025010628.2
XP_025010629.2
XP_040502858.1
XP_040502859.1
XP_040502860.1
XP_040502861.1
XP_046756336.1
XP_046756337.1
XP_046756339.1
XP_046782968.1
XP_046782969.1
XP_046782970.1
XP_046782971.1
XP_046782972.1
XP_046782973.1
XP_046782974.1
XP_046782975.1
XP_046782976.1
XP_046782977.1
XP_046782978.1
XP_046782979.1
XP_046782980.1
XP_046782981.1
XP_046782982.1
XP_046782983.1
XP_046782985.1
XP_046782986.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006155.1 → NP_001006155.1  prolyl 4-hydroxylase subunit alpha-2 precursor

    See identical proteins and their annotated locations for NP_001006155.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ719729
    UniProtKB/Swiss-Prot
    Q5ZLK5
    UniProtKB/TrEMBL
    Q5W4S2
    Related
    ENSGALP00010022540.1, ENSGALT00010039027.1
    Conserved Domains (2) summary
    smart00702
    Location:347 → 518
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:27 → 113
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    16344620..16368673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046900381.1 → XP_046756337.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YV98, Q5W4S2

  2. XM_025154860.3 → XP_025010628.2  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2
    Conserved Domains (1) summary
    smart00702
    Location:347 → 520
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  3. XM_040646926.2 → XP_040502860.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZLK5
    UniProtKB/TrEMBL
    Q5W4S2
    Conserved Domains (2) summary
    smart00702
    Location:347 → 518
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:27 → 113
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  4. XM_046900380.1 → XP_046756336.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2

  5. XM_015294023.4 → XP_015149509.2  prolyl 4-hydroxylase subunit alpha-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YV98, Q5W4S2
    Related
    ENSGALP00010022545.1, ENSGALT00010039037.1
    Conserved Domains (1) summary
    smart00702
    Location:347 → 498
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  6. XM_015294022.4 → XP_015149508.2  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2
    Conserved Domains (1) summary
    smart00702
    Location:347 → 520
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  7. XM_046900383.1 → XP_046756339.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YV98, Q5W4S2

  8. XM_040646924.2 → XP_040502858.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2
    Conserved Domains (1) summary
    smart00702
    Location:347 → 520
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  9. XM_025154859.3 → XP_025010627.2  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2
    Related
    ENSGALP00010022530.1, ENSGALT00010039002.1
    Conserved Domains (1) summary
    smart00702
    Location:347 → 520
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  10. XM_025154861.3 → XP_025010629.2  prolyl 4-hydroxylase subunit alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZLK5
    UniProtKB/TrEMBL
    Q5W4S2
    Conserved Domains (2) summary
    smart00702
    Location:347 → 518
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:27 → 113
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  11. XM_040646925.2 → XP_040502859.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2
    Conserved Domains (1) summary
    smart00702
    Location:347 → 520
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  12. XM_040646927.2 → XP_040502861.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZLK5
    UniProtKB/TrEMBL
    Q5W4S2
    Related
    ENSGALP00010022534.1, ENSGALT00010039013.1
    Conserved Domains (2) summary
    smart00702
    Location:347 → 518
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:27 → 113
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  13. XM_015294026.4 → XP_015149512.2  prolyl 4-hydroxylase subunit alpha-2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YWU9
    Related
    ENSGALP00010022523.1, ENSGALT00010038987.1
    Conserved Domains (1) summary
    smart00702
    Location:347 → 458
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    16356221..16380367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046927026.1 → XP_046782982.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YV98, Q5W4S2

  2. XM_046927019.1 → XP_046782975.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2

  3. XM_046927022.1 → XP_046782978.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZLK5
    UniProtKB/TrEMBL
    Q5W4S2

  4. XM_046927013.1 → XP_046782969.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YV94, Q5W4S2

  5. XM_046927016.1 → XP_046782972.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YV94, Q5W4S2

  6. XM_046927025.1 → XP_046782981.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YV98, Q5W4S2

  7. XM_046927018.1 → XP_046782974.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2

  8. XM_046927012.1 → XP_046782968.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YV94, Q5W4S2

  9. XM_046927027.1 → XP_046782983.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YV98, Q5W4S2

  10. XM_046927015.1 → XP_046782971.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YV94, Q5W4S2

  11. XM_046927020.1 → XP_046782976.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2

  12. XM_046927023.1 → XP_046782979.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZLK5
    UniProtKB/TrEMBL
    Q5W4S2

  13. XM_046927014.1 → XP_046782970.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YV94, Q5W4S2

  14. XM_046927021.1 → XP_046782977.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q5W4S2

  15. XM_046927024.1 → XP_046782980.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    Q5ZLK5
    UniProtKB/TrEMBL
    Q5W4S2

  16. XM_046927017.1 → XP_046782973.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YV94, Q5W4S2

  17. XM_046927029.1 → XP_046782985.1  prolyl 4-hydroxylase subunit alpha-2 isoform X6

    UniProtKB/TrEMBL
    A0A8V0YUU1

  18. XM_046927030.1 → XP_046782986.1  prolyl 4-hydroxylase subunit alpha-2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YWU9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZLK5.1 GenPept UniProtKB/Swiss-Prot:Q5ZLK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials