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MCAM melanoma cell adhesion molecule [ Homo sapiens (human) ]

Gene ID: 4162, updated on 1-Jun-2020

Summary

Official Symbol
MCAMprovided by HGNC
Official Full Name
melanoma cell adhesion moleculeprovided by HGNC
Primary source
HGNC:HGNC:6934
See related
Ensembl:ENSG00000076706 MIM:155735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD146; MUC18; HEMCAM; METCAM; MelCAM
Expression
Broad expression in fat (RPKM 237.1), placenta (RPKM 102.0) and 17 other tissues See more
Orthologs

Genomic context

See MCAM in Genome Data Viewer
Location:
11q23.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119305759..119317130, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119179234..119189087, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene fragile site, folic acid type, rare, fra(11)(q23.3) Neighboring gene Cbl proto-oncogene Neighboring gene RNA, U6 small nuclear 262, pseudogene Neighboring gene microRNA 6756 Neighboring gene ring finger protein 26 Neighboring gene C1q and TNF related 5 Neighboring gene membrane frizzled-related protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
glomerular filtration IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
vascular wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region HDA PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
cell surface glycoprotein MUC18
Names
Gicerin
S-endo 1 endothelial-associated antigen
cell surface glycoprotein P1H12
melanoma adhesion molecule
melanoma-associated antigen A32
melanoma-associated antigen MUC18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006500.3NP_006491.2  cell surface glycoprotein MUC18 precursor

    See identical proteins and their annotated locations for NP_006491.2

    Status: VALIDATED

    Source sequence(s)
    AB209925, AP002956, AU076908, BC056418
    Consensus CDS
    CCDS31690.1
    UniProtKB/Swiss-Prot
    P43121
    UniProtKB/TrEMBL
    A0A024R3I5
    Related
    ENSP00000264036.4, ENST00000264036.6
    Conserved Domains (3) summary
    pfam08205
    Location:139234
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:261321
    Ig_3; Immunoglobulin domain
    cl11960
    Location:450510
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    119305759..119317130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017762.2XP_016873251.1  cell surface glycoprotein MUC18 isoform X4

  2. XM_017017759.2XP_016873248.1  cell surface glycoprotein MUC18 isoform X1

  3. XM_017017760.2XP_016873249.1  cell surface glycoprotein MUC18 isoform X2

  4. XM_017017761.2XP_016873250.1  cell surface glycoprotein MUC18 isoform X3

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